Authors :
Dr. Vijay Kumar Dahiya; Dr. Ekta; Dr. Himanshu Goel
Volume/Issue :
Volume 11 - 2026, Issue 6 - June
Google Scholar :
https://tinyurl.com/yhkn5kwp
Scribd :
https://tinyurl.com/ydr2mejt
DOI :
https://doi.org/10.38124/ijisrt/26jun2027
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Background:
Acute Lymphoblastic Leukemia (ALL) is the most common pediatric malignancy, accounting for nearly 25–30% of all
childhood cancers. Early recognition of its clinical manifestationsis crucial for timely diagnosis, prompt initiation of therapy,
and improved survival. Information regarding the clinical profile of childhood ALL from rural regions of Southern Haryana
remains limited.
Objectives:
To evaluate the demographic characteristics, clinical presentation, physical findings, and baseline hematological
parameters of children diagnosed with Acute Lymphoblastic Leukemia at a tertiary care teaching hospital serving
predominantly rural Southern Haryana.
Methods:
A retrospective observational study was conducted in the Department of Pediatrics, NC Medical College & Hospital,
Israna, Haryana. Medical records of children (0–18 years) diagnosed with ALL between January 2021 and December 2025
were reviewed.
Keywords :
Acute Lymphoblastic Leukemia, Childhood Cancer, Clinical Presentation, Rural Haryana, Hematological Malignancy.
References :
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- Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet. 2008;371(9617):1030-1043. doi:10.1016/S0140-6736(08)60457-2.
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- Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015;373(16):1541-1552. doi:10.1056/NEJMra1400972.
- Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354(2):166-178. doi:10.1056/NEJMra052603.
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- Gogoi MP, Das P, Das N, et al. Risk stratified treatment for childhood acute lymphoblastic leukaemia: a multicentre observational study from India. Lancet Reg Health Southeast Asia. 2025;37:100593. doi:10.1016/j.lansea.2025.100593.
- Sarkar SD, Maiti D, Ghosh A, Ganguly M, Ahmed N. Immunophenotypic and cytogenetic characteristics of pediatric acute lymphoblastic leukemia: a burden estimation study from Eastern India. Indian J Public Health. 2024;68(1):21-25. doi:10.4103/ijph.ijph_889_23.
- Pandita A, Harish R, Digra SK, Raina A, Sharma AA, Koul A. Molecular cytogenetics in childhood acute lymphoblastic leukemia: a hospital-based observational study. Clin Med Insights Oncol. 2015;9:39-42. doi:10.4137/CMO.S24463.
- Acharya S, Maiti D, Datta S. Clinico-epidemiological study of extramedullary disease manifestations in childhood acute lymphoblastic leukaemia in a tertiary care centre. Int J Contemp Pediatr. 2018;5(4):1637-1640. doi:10.18203/2349-3291.ijcp20182580.
- Siddaiahgari SR, Awaghad MA, Latha MS. Clinical, immunophenotype and cytogenetic profile of acute lymphoblastic leukemia in children at a tertiary health care centre in India. Muller J Med Sci Res. 2015;6(2):112-118. doi:10.4103/0975-9727.160676.
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Background:
Acute Lymphoblastic Leukemia (ALL) is the most common pediatric malignancy, accounting for nearly 25–30% of all
childhood cancers. Early recognition of its clinical manifestationsis crucial for timely diagnosis, prompt initiation of therapy,
and improved survival. Information regarding the clinical profile of childhood ALL from rural regions of Southern Haryana
remains limited.
Objectives:
To evaluate the demographic characteristics, clinical presentation, physical findings, and baseline hematological
parameters of children diagnosed with Acute Lymphoblastic Leukemia at a tertiary care teaching hospital serving
predominantly rural Southern Haryana.
Methods:
A retrospective observational study was conducted in the Department of Pediatrics, NC Medical College & Hospital,
Israna, Haryana. Medical records of children (0–18 years) diagnosed with ALL between January 2021 and December 2025
were reviewed.
Keywords :
Acute Lymphoblastic Leukemia, Childhood Cancer, Clinical Presentation, Rural Haryana, Hematological Malignancy.