Authors :
Dastan Salim Hassan; Hemin Jumaa Majeed Hasary
Volume/Issue :
Volume 7 - 2022, Issue 5 - May
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3xYxWo1
DOI :
https://doi.org/10.5281/zenodo.6655187
Abstract :
Cyclophosphamide (Cytoxan; Cy) is an
alkylating agent with immunosuppressive and cytotoxic
action. The origin compound is out of action in vitro and
utilizesits biologic activity over metabolites, principally
phosphoramide mustard stemming from hepatic
microsomal enzymes. The accurate process of cytotoxic
and immunosuppressive activity of Cy at the cellular
level is not ultimately presumed. Myelosuppression,
alopecia, hemorrhagic cystitis, and gonadal disturbance
are the main harmful consequence. Applicable
information proposesthat Cy has carcinogenic probable
in humans. Cy is greatly utilized as chemotherapy for
cancer treatment, also as an immunosuppressive
chemical, it is profitably used in specific nonmalignant
diseases whether autoimmune phenomena are
entrenched or suspicious in the pathogenesis of the
disease. It is the preferred drug in Wegener's
granulomatosis. Broad efforts are being made to
generate Cy analogues with higher selective cytotoxic
and immunosuppressive activity.
Keywords :
Cyclophosphamide, cyclophosphamide and cancer, chemotherapy, toxic effect.
Cyclophosphamide (Cytoxan; Cy) is an
alkylating agent with immunosuppressive and cytotoxic
action. The origin compound is out of action in vitro and
utilizesits biologic activity over metabolites, principally
phosphoramide mustard stemming from hepatic
microsomal enzymes. The accurate process of cytotoxic
and immunosuppressive activity of Cy at the cellular
level is not ultimately presumed. Myelosuppression,
alopecia, hemorrhagic cystitis, and gonadal disturbance
are the main harmful consequence. Applicable
information proposesthat Cy has carcinogenic probable
in humans. Cy is greatly utilized as chemotherapy for
cancer treatment, also as an immunosuppressive
chemical, it is profitably used in specific nonmalignant
diseases whether autoimmune phenomena are
entrenched or suspicious in the pathogenesis of the
disease. It is the preferred drug in Wegener's
granulomatosis. Broad efforts are being made to
generate Cy analogues with higher selective cytotoxic
and immunosuppressive activity.
Keywords :
Cyclophosphamide, cyclophosphamide and cancer, chemotherapy, toxic effect.
