Authors :
Hamza Oualhadj; Ayoub Rafei; Fatima ezzahra Bouanani; Amine Haouane; Wafa Quiddi; Amine Azami; Sanae Sayagh
Volume/Issue :
Volume 9 - 2024, Issue 5 - May
Google Scholar :
https://tinyurl.com/2793ba2p
Scribd :
https://tinyurl.com/2b7us5fr
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAY2008
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Mantle cell lymphoma (MCL) is a rare and
aggressive subtype of non-Hodgkin lymphoma (NHL)
originating from cells in the mantle zone. Herein, we
present a case report of a 49-year-old male patient
diagnosed with stage VI MCL, illustrating various
diagnostic methods and procedures utilized in his
evaluation. The patient presented with progressively
enlarging cervical lymph nodes, fatigue, weight loss,
anorexia, chronic diarrhea, abdominal pain, and rectal
bleeding. Clinical examination revealed cutaneomucosal
pallor, tachycardia, expiratory polypnea, bilateral
jugulocarotid adenopathies, and splenomegaly.
Laboratory investigations showed normocytic
normochromic anemia, hyperleukocytosis, lymphocytic
predominance, and thrombocytopenia. Peripheral blood
smear analysis indicated a lymphoproliferative disorder,
confirmed by flow cytometry revealing monotypic
lymphoid cells. Bone marrow biopsy showed hypoplastic
marrow with atypical cells. Immunohistochemistry
confirmed mantle cell lymphoma localization.
Subsequent thoraco-abdomino-pelvic CT scan revealed
mediastinal and abdominal adenopathy with
splenomegaly, leading to a diagnosis of stage IV MCL.
The case highlights the importance of early and
comprehensive diagnostic approaches in MCL
management.
Keywords :
Mantle Cell Lymphoma; Diagnosis; Rare; Case Report.
References :
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- Kurtin PJ. Mantle cell Lymphoma. Adv Anat Pathol. 1998;5(6):376–98.
- Maddocks K. Update on mantle cell lymphoma. Vol. 132, Blood. 2018.
- Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY. New Directions for Mantle Cell Lymphoma in 2022. American Society of Clinical Oncology Educational Book. 2022 Jul;(42):614–28.
- Le Gouill S. Lymphome à cellules du manteau. 2010.
- Eyre TA, Bishton MJ, McCulloch R, O’Reilly M, Sanderson R, Menon G, et al. Diagnosis and management of mantle cell lymphoma: A British Society for Haematology Guideline. Br J Haematol. 2024 Jan 1;204(1):108–26.
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- Mai B, Saluja K, Hu Z, Nguyen ND, Wahed A, Iris Wang X, et al. Educational Case Educational Case: Mantle Cell Lymphoma Primary Objective Objective HWC3.1: Morphology of Acute Leukemia and Lym-phoma. Describe the morphologic features that characterize typical cases of acute leukemia and lymphoma. Competency 2: Organ System Pathology; Topic Hemato-pathology-White Cell Disorders (HWC); Learning Goal 3: Classification of Leukemia and Lymphomas. Patient Presentation What Is the First-Line Treatment for Acute Sinusitis? Acad Pathol [Internet]. 7. Available from: http://journals.sagepub.com/
- Siek J, Sysiak-Sławecka J. Patient diagnosed with mantle cell lymphoma with tumour lysis syndrome – Case Report and literature review. Journal of Pre-Clinical and Clinical Research. 2023 May 25;
- Herrera-Gonzalez S, Shamoon D, Shen T, Badin S, Bains Y. A Unique Case of Mantle Cell Lymphoma Masquerading as a Cecal Mass. Case Rep Gastrointest Med. 2021 Sep 10;2021:1–5.
- Smith BM, Reilly K, Baker E, Deeken A, Dan AG. A case report of mantle cell lymphoma presenting as intussuscepting colon mass. Int J Surg Case Rep. 2020 Jan 1;69:28–31.
Mantle cell lymphoma (MCL) is a rare and
aggressive subtype of non-Hodgkin lymphoma (NHL)
originating from cells in the mantle zone. Herein, we
present a case report of a 49-year-old male patient
diagnosed with stage VI MCL, illustrating various
diagnostic methods and procedures utilized in his
evaluation. The patient presented with progressively
enlarging cervical lymph nodes, fatigue, weight loss,
anorexia, chronic diarrhea, abdominal pain, and rectal
bleeding. Clinical examination revealed cutaneomucosal
pallor, tachycardia, expiratory polypnea, bilateral
jugulocarotid adenopathies, and splenomegaly.
Laboratory investigations showed normocytic
normochromic anemia, hyperleukocytosis, lymphocytic
predominance, and thrombocytopenia. Peripheral blood
smear analysis indicated a lymphoproliferative disorder,
confirmed by flow cytometry revealing monotypic
lymphoid cells. Bone marrow biopsy showed hypoplastic
marrow with atypical cells. Immunohistochemistry
confirmed mantle cell lymphoma localization.
Subsequent thoraco-abdomino-pelvic CT scan revealed
mediastinal and abdominal adenopathy with
splenomegaly, leading to a diagnosis of stage IV MCL.
The case highlights the importance of early and
comprehensive diagnostic approaches in MCL
management.
Keywords :
Mantle Cell Lymphoma; Diagnosis; Rare; Case Report.