COVID-19 has become a global pandemic with the spectrum of disease from asymptomatic to severe cases requiring intensive care unit admissions linked to higher mortality.The reported clinical profiles varied among different geographical regions and there was a scarcity of data of COVID-19 in our scenario. Thus we aimed to describe the epidemiological and clinical profiles of COVID-19 patients admitted at Bheri Hospital, Nepalgunj, Nepal. Methods: A retrospective cross-sectional study was conducted from September to November 2020, among COVID-19 cases admitted at Bheri Hospital. The sociodemographic data, clinical features, comorbidities, treatment and outcome data were entered in Microsoft Excel and analyzed using statistical package for social science (SPSS) version 20. Results: Of 428 patients 58.87 % were male with 66.5% of patients in 20 to 50 years age group. Fever (75.70%) was the most common symptom followed by cough and myalgia with 69.15%, 44.15% respectively. Diabetes (11.21%) and hypertension (9.57%) was common comorbidities. Deranged liver enzymes (AST 44%, ALT 46%), followed by neutrophilia (39%), lymphopenia (32%) were common laboratory findings. Patchy infiltrates, ground glass opacity and consolidation were common X-ray findings with 13%, 10%, and 9% respectively. Remdesivir was used in 8.17%, convalescent plasma therapy in 2.1% and both in 5.67% of the patients. 22.18% patients required ICU admissions. The case fatality rate was 0.86% within the study period. Conclusions: This study demonstrates that middle-aged patients with pre-existing comorbid conditions present with relatively severe COVID-19 disease and have poorer outcomes.

Keywords : COVID-19; Clinical Profile; Epidemiological Study; Pandemic