Chronobiological Disruption and Metabolic Dysregulation in the 24-Hour Economy: A Narrative Review


Authors : M. Bharath Bala; R. Yogalakshmi; Dr. Muthu Gopal

Volume/Issue : Volume 10 - 2025, Issue 12 - December


Google Scholar : https://tinyurl.com/ykft4a87

Scribd : https://tinyurl.com/3yfyxb6f

DOI : https://doi.org/10.38124/ijisrt/25dec1203

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Background The transition to a 24-hour economy has necessitated a workforce that operates in opposition to endogenous circadian rhythms. Night shift work is increasingly recognized not merely as a logistical requirement but as a significant occupational health hazard associated with sleep disorders, metabolic syndrome, and cardiovascular disease.  Methods A narrative review of the literature was conducted using PubMed, Embase, and Google Scholar databases. The search targeted studies published between 2015 and 2025 focusing on "circadian misalignment," "night shift work," "chrononutrition," and "sleep quality." Special attention was given to recent data regarding Information Technology (IT) professionals and high-cognitive-demand sectors.  Results The literature consistently demonstrates a high prevalence of poor sleep quality among night shift workers, with recent cohort studies in IT sectors reporting prevalence rates as high as 100% (PSQI > 5). Evidence identifies a bidirectional relationship between sleep disturbance and maladaptive dietary behaviors, specifically increased food frequency and nocturnal snacking. Physiologically, this is driven by the desynchronization of the central suprachiasmatic nucleus (SCN) and peripheral metabolic clocks, characterized by inverted leptin-ghrelin profiles and insulin resistance.  Discussion The core pathology of night shift work is chronic circadian misalignment. The negative correlation between food frequency and sleep quality suggests that "grazing" behaviors act as a zeitgeber that further desynchronizes peripheral clocks. Mitigation strategies must move beyond basic sleep hygiene to include organizational changes (forward-rotating schedules, spectral light management) and individual chrononutritional interventions (Early Time-Restricted Eating).  Conclusion Night shift work induces systemic physiological dysregulation. Future research must prioritize longitudinal studies to overcome the "healthy worker effect" and establish causal pathways for the metabolic risks observed.

References :

  1. Bala MB, et al. Impact of night shift work on sleep quality and dietary pattern: a study among IT professionals in Puducherry, India. Int J Community Med Public Health. 2025;12(2):880-886.
  2. Dutheil F, et al. The Impact of Night Work on the Sleep and Health of Medical Staff A Review of the Latest Scientific Reports. J Clin Med. 2025.
  3. James SM, et al. Shift Work and Sleep: Medical Implications and Management. Sleep Med Clin. 2018.
  4. Kecklund G, Axelsson J. Health consequences of shift work and insufficient sleep. BMJ. 2016.
  5. Abbott SM, et al. Consequences of Circadian Disruption in Shift Workers on Chrononutrition and their Psychosocial Well-Being. Int J Environ Res Public Health. 2020.
  6. Sun Q, et al. Prevalence of insomnia in shift workers: a systematic review. Sleep Breath. 2021.
  7. Gupta CC, et al. The effect of shift work on eating habits: a systematic review. Scand J Work Environ Health. 2019.
  8. McHill AW, Wright KP. Role of sleep and circadian disruption on energy balance and diabetes: a summary of CDC activities. Curr Diab Rep. 2017.
  9. Chellappa SL, et al. Impact of circadian misalignment on energy metabolism during simulated nightshift work. PNAS. 2014.
  10. Lowden A, et al. Eating and shift work - effects on habits, metabolism and performance. Scand J Work Environ Health. 2010.

Background The transition to a 24-hour economy has necessitated a workforce that operates in opposition to endogenous circadian rhythms. Night shift work is increasingly recognized not merely as a logistical requirement but as a significant occupational health hazard associated with sleep disorders, metabolic syndrome, and cardiovascular disease.  Methods A narrative review of the literature was conducted using PubMed, Embase, and Google Scholar databases. The search targeted studies published between 2015 and 2025 focusing on "circadian misalignment," "night shift work," "chrononutrition," and "sleep quality." Special attention was given to recent data regarding Information Technology (IT) professionals and high-cognitive-demand sectors.  Results The literature consistently demonstrates a high prevalence of poor sleep quality among night shift workers, with recent cohort studies in IT sectors reporting prevalence rates as high as 100% (PSQI > 5). Evidence identifies a bidirectional relationship between sleep disturbance and maladaptive dietary behaviors, specifically increased food frequency and nocturnal snacking. Physiologically, this is driven by the desynchronization of the central suprachiasmatic nucleus (SCN) and peripheral metabolic clocks, characterized by inverted leptin-ghrelin profiles and insulin resistance.  Discussion The core pathology of night shift work is chronic circadian misalignment. The negative correlation between food frequency and sleep quality suggests that "grazing" behaviors act as a zeitgeber that further desynchronizes peripheral clocks. Mitigation strategies must move beyond basic sleep hygiene to include organizational changes (forward-rotating schedules, spectral light management) and individual chrononutritional interventions (Early Time-Restricted Eating).  Conclusion Night shift work induces systemic physiological dysregulation. Future research must prioritize longitudinal studies to overcome the "healthy worker effect" and establish causal pathways for the metabolic risks observed.

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Paper Submission Last Date
31 - January - 2026

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