Authors : Felic S; N Praveen; Kezia K Sabu; Dr. K C Arulprakasam

Volume/Issue : Volume 9 - 2024, Issue 2 - February

Google Scholar : http://tinyurl.com/msdn2ct5

Scribd : http://tinyurl.com/yasmxjfu

DOI : https://doi.org/10.5281/zenodo.10669409

Abstract : One percent of people have celiac disease (CD), a prevalent autoimmune illness. When gluten is consumed by vulnerable people, an immune-mediated enteropathy may arise. In order to provide energy and nutrition, a major grain crop called wheat is used by billions of people worldwide. Gluten, a structural element of wheat, is crucial to the grain's capacity to produce dough, but it can also make some people susceptible to certain intolerances.The three primary genetic components of CD differentiate it from other autoimmune illness. These components include the auto- antigen responsible for the disease (tissue transglutaminase [tTG], the environmental trigger (gluten), and human leukocyte antigen (HLA)-DQ8.A gluten-free diet (GFD) is the only treatment for celiac disease (CeD), while it may also assist those with non- celiac gluten/wheat sensitivity feel less symptomatic. Different diseases have different causes for when they start and manifest; some, like type 1 diabetes mellitus (T1D), have comparable pathogenic pathways, while others have no known etiology. It is important for general practitioners and other specialists to remember that CD might present with extraintestinal symptoms at initially and that the disease can worsen concurrent conditions even as it advances.

Keywords : Celiac Disease, Gluten Allergy, Rho/Rho Kinase Inhibition, Tissue Transglutaminase, Deamidated Gliadin Peptides, Recurrent Aphthous Stomatitis.