Authors : Dr. Oyindamola Olaniyi Oyesaga

Volume/Issue : Volume 9 - 2024, Issue 5 - May

Google Scholar : https://tinyurl.com/y5fbwx7r

Scribd : https://tinyurl.com/4c354etk

DOI : https://doi.org/10.38124/ijisrt/IJISRT24MAY1738

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Cerebrovascular disease generally refers to the abnormality of the brain, and it is usually caused by the pathologic process of blood vessels. After heart disease and cancer, stroke is the third most common cause of death in the developed world. Stroke can be classified based on the evolution and duration of the symptoms experienced by the patient. From the perspectives of human, family, and the society, stroke is a costly disease. In 2015, the total cost of stroke in the EU was estimated at about €45 Billion. Also, in the same year, the total direct and indirect cost of stroke in the United States of America was calculated as $103.50 billion annually. Meanwhile, stroke can be conveniently classified as two processes, based on pathologic anatomy and pathophysiology. The first process is; hpoxia, ischaemia, and infarction. This is usually caused by the pathology of blood supply and the impairment of oxygenation to the central nervous system (CNS) tissue. The second process is haemorrhage, and this is usually due to the rupture of blood vessels to the CNS. Most of the thrombotic arterial occlusions are caused by atherosclerosis, while primary brain parenchymal haemorrhage is most commonly due to hypertension. Cellular medicine is an approach to healthcare which focuses on the aetiology of diseases and develops treatment for the diseases by studying; biological processes, structures and functions of biomolecules, and cell physiology, in order to understand abnormal biological function at the cellular level. Research in the field of cellular medicine have revealed that atherosclerosis, the main cause of cardiovascular and cerebrovascular diseases, can be reversed using cellular medicine. The research also showed that atherosclerosis is an early form of full blown scurvy, thus both scurvy and atherosclerosis have the same cause, which is vitamin C deficiency.

Keywords : Stroke, Cellular Medicine, High Dose Vitamin C, Atherosclerosis, Hypertension, Lipoprotein (A).

References :

1. K. Vinay, K.A. Abul, and F. Nelson,  Robin and Cotran Pathologic Basis of Disease, 7th ed. Elsevier; 1999.
2. A.B. Nicholas, R.C. Nicki, R.W. Brian, A.H. John, and B. Robert, Davidson’s Principles & Practice of Medicine, 20th ed. Elsevier; 2006.
3. WHO. Cardiovascular Disease, https://www.who.int/ news-room/fact-sheets/detail/cardiovascular-diseaess-(cvds); 2017 [accessed 19 September 2019].
4. Stroke Alliance For Europe. The burden of stroke in Europe, https://www.strokeeurope.eu/index/the-burden-of-stroke-in-europe/1-8-the-financial-and-social-burden-of-stroke/; 2015 [accessed 19 September 2019].
5. Neuro News. Cost analysis concludes that the direct cost of stroke, at US $ 35 billion annually, represents only the tip of the iceberg; https://www.neuronewsinternational.com/cost-analysis-concludes-that-the-direct-cost-of-stroke-at-us35-billion-annually-represents-only-the-tip-of-the-iceberg/; 2019 [accessed 19 September 2019].
6. American Stroke Association. Types of Stroke, https://www.stroke.org/en/about-stroke/types-of-stroke; [accessed 19 September 2019].
7. AHA / ASA Journals. Heart Disease and Stroke Statistics – 2018 Update: A Report From the American Heart Association, https://www.ahajournals.org/doi/full/ 10.1161/cir.0000000000000558; 2018 [accessed 19 September 2019].
8. A.O. Falase and O.O. Akinkungbe, A Compendium of Clinical Medicine. New ed. Spectrum; 2007.
9. Insight Medical Publisishing. Cellular & Molecular Medicine: Open access, https://www.imedpub.com/ scholarly/cellular-medicine-journals-articles-ppts-list. php; [accessed 19 September 2019].
10. Dr Rath M. Cellular Medicine Foundation Course. 2012.
11. K.M. Robert, K.G. Daryl, A.M. Peter, and W.R. Victor, Harper’s Illustrated Biochemistry. 26th ed. Mc Graw Hill; 2003.
12. C. John, N. Aleksandra, and R. Mathias, “Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice,” Am J Cardiovasc Dis, 2015;5(1): 53-62.
13. S. Wallace, and A. Wallace, “New Look at Atherosclerosis,” Repeatable Science Ushers in a New Era of Medicine. J Cardiol Curr Res 2017;9(5): 00341.
14. AIBB. Linus Pauling Protocol, https://www.associacionaibb.com/linus-pauling-protocol; [accessed 19 September 2019].
15. R.F. Cathcart, “Vitamin C, Titrating to Bowel Tolerance, Anascorbemia and Acute Induced Scurvy.” Medical Hypothesis, 1981;7(11): 1359 – 1376
16. The NNT. Statins in Persons at Low Risk of Cardiovascular Disease, https://www.thennt.com/nnt/ statins-person-low-risk-cardiovascular-disease/; [accessed 19 September 2019]