Carbonic anhydrase (CA) has a significant role in abnormal cellular proliferation and might serve as a novel biomarker for cancer. Cellular level studies of several CA isoforms for CA inhibition potential had shown the role of CA in cancer pathways. The distinct tumor-associated CA isoforms identified in humans can be the targets for the potential approach in cancer therapeutics. Targeting these distinct isoforms in human tumorigenesis, by identifying CA inhibitors from plants, can be the answer to an advanced therapeutic strategy through personal therapy. Novel biomarkers of CA isoforms based on gene data and experimental results retrieved from literature to model a 3D protein sequence were developed using computational strategies.

Keywords : Carbonic Anhydrase, Biomarker, QSAR.