Authors :
Lungu N. Claudiu
Volume/Issue :
Volume 4 - 2019, Issue 11 - November
Google Scholar :
https://goo.gl/DF9R4u
Scribd :
https://bit.ly/37X52W4
Abstract :
Carbonic anhydrase (CA) has a significant
role in abnormal cellular proliferation and might serve
as a novel biomarker for cancer. Cellular level studies of
several CA isoforms for CA inhibition potential had
shown the role of CA in cancer pathways. The distinct
tumor-associated CA isoforms identified in humans can
be the targets for the potential approach in cancer
therapeutics. Targeting these distinct isoforms in human
tumorigenesis, by identifying CA inhibitors from plants,
can be the answer to an advanced therapeutic strategy
through personal therapy. Novel biomarkers of CA
isoforms based on gene data and experimental results
retrieved from literature to model a 3D protein
sequence were developed using computational
strategies.
Keywords :
Carbonic Anhydrase, Biomarker, QSAR.
Carbonic anhydrase (CA) has a significant
role in abnormal cellular proliferation and might serve
as a novel biomarker for cancer. Cellular level studies of
several CA isoforms for CA inhibition potential had
shown the role of CA in cancer pathways. The distinct
tumor-associated CA isoforms identified in humans can
be the targets for the potential approach in cancer
therapeutics. Targeting these distinct isoforms in human
tumorigenesis, by identifying CA inhibitors from plants,
can be the answer to an advanced therapeutic strategy
through personal therapy. Novel biomarkers of CA
isoforms based on gene data and experimental results
retrieved from literature to model a 3D protein
sequence were developed using computational
strategies.
Keywords :
Carbonic Anhydrase, Biomarker, QSAR.
