Authors : Amrita Mohanty; Gowhar Iqbal; Lukram Sushil Singh; Viral Kumar Ganpatbhai

Volume/Issue : Volume 8 - 2023, Issue 7 - July

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/4yn5r2uc

DOI : https://doi.org/10.5281/zenodo.8181065

Abstract : Naturally, mRNA is a single-stranded structure consisting of an (m7g) 7-methyl-guanosine position at 5’end and 3’end consisting of a poly (A) tail. mRNA has emerged as a novel potential drug candidate and has wide applications in cancer immunotherapy, gene therapy, infectious disease vaccines, and cellular genetic engineering. Extension of the half-life of mRNA can be achieved by introducing some stabilizing elements into UTR regions. Employing mRNA for its therapeutical prospects holds various characteristics such as simple modifications, faster and transitory presentation, and compatibility lacking mutagenesis, which are important for treating various diseases. mRNA has emerged as a novel potential drug candidate and has wide applications in cancer immunotherapy, gene therapy, infectious disease vaccines, and cellular genetic engineering. In recent years, mRNA has proved itself a novel therapeutic drug.

Keywords : mRNA, Therapeutics, Immunotherapy, mRNA Delivery,