Authors : Dr Supra Ratan Karkera; Dr Manjushree Kadam; Dr Devishree CP; Dr Yashaswi Shetty; Dr Riolla Sanchia Dsouza

Volume/Issue : Volume 9 - 2024, Issue 8 - August

Google Scholar : https://shorturl.at/hS7QR

Scribd : https://shorturl.at/e31Uk

DOI : https://doi.org/10.38124/ijisrt/IJISRT24AUG218

Abstract : The field of periodontology and dental implantology has witnessed significant advancements in the use of molecular mediators and biologic agents over the past decade. Periodontal regeneration, which involves the complete restoration of cementum, bone, and connective tissue following removal of epithelial tissues, is considered superior to tissue repair. Recent research has focused on utilizing biologic materials as complementary therapies to enhance regeneration by accelerating wound healing. These biologic agents were investigated using the following search terms: tissue engineering, intercellular signaling molecules, and biological factors. Enamel matrix derivative (EMD), platelet-derived growth factor (PDGF), platelet-rich plasma, bone morphogenetic proteins (BMPs), fibroblast growth factor (FGF), and parathyroid hormone (PTH) have demonstrated the capacity to stimulate both hard and soft tissue regeneration. However, no single biologic agent is universally effective, necessitating a case-by-case evaluation for optimal treatment selection. Currently, EMD and PDGF are the only biologic therapies approved by the FDA for periodontal regeneration, while BMP-2 is indicated for bone augmentation. Due to a lack of FDA approval for periodontal applications, the clinical use of FGF and PTH in this context is not recommended.

Keywords : Periodontal Regeneration, Enamel Matrix Derivative, Platelet Rich Fibrin, Platelet Derived Growth Factors, 3d Scaffolds, Biologics, Open Flap Debridement, Bone Morphogenic Proteins, Insulin Like Growth Factor, Fibroblast Growth Factors.

References :

1. Galli M, Yao Y, Giannobile WV, Wang HL. Current and future trends in periodontal tissue engineering and bone regeneration. Plastic and aesthetic research. 2021;8.
2. Monje A, Suárez‐López del Amo F. Application of biologics for ridge preservation/reconstruction after implant removal. Clinical Advances in Periodontics. 2022 ;12(4):270-6.
3. Fan L, Wu D. Enamel matrix derivatives for periodontal regeneration: recent developments and future perspectives. Journal of Healthcare Engineering. 2022
4. Swanson WB, Yao Y, Mishina Y. Novel approaches for periodontal tissue engineering. genesis. 2022 ;60(8-9):e23499.
5. Hari Priya N, Mohan Kumar P, Keerthi V, Penmetsa GS, NVS Sruthima G, Ramesh KSV. Role of biologic modifiers in periodontal regeneration- A review. IP Int J Periodontol Implantol 2022;7(4):145-149
6. Pendyala GS, Shetty G, Nelson A, Pillai SS, Satheesh T, Medikonda M. BONE MORPHOGENIC PROTEINS-A REVIEW. Journal of Pharmaceutical Negative Results. 2022 :2834-6.
7. Ausenda F, Rasperini G, Acunzo R, Gorbunkova A, Pagni G. New perspectives in the use of biomaterials for periodontal regeneration. Materials. 2019 ;12(13): 2197
8. d’Avanzo N, Bruno MC, Giudice A, Mancuso A, Gaetano FD, Cristiano MC, Paolino D, Fresta M. Influence of materials properties on bio-physical features and effectiveness of 3D-scaffolds for periodontal regeneration. Molecules. 2021;26(6): 1643.
9. Kaigler D, Avila G, Wisner-Lynch L, Nevins ML, Nevins M, Rasperini G, Lynch SE, Giannobile WV. Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration. Expert opinion on biological therapy. 2011 ;11(3): 375-85
10. Agrawal M, Agrawal V. Platelet rich fibrin and its applications in dentistry-A review article. National Journal of Medical and Dental Research. 2014 1;2(3):51.
11. Mani R, Mahantesha S, Nandini TK, Lavanya R. Growth Factors in Periodontal Regeneration. Journal of Advanced Oral Research. 2014 May 1;5(2)
12. Verma NK, Ompal SS, Prakash P, Mukherjee M, Jha AK. Recent advances in materials for periodontal regeneration. Journal of Dentistry Defence Section. 2021 ;15(2):130.
13. Darby IB, Morris KH. A systematic review of the use of growth factors in human periodontal regeneration. Journal of Periodontology. 2013 ;84(4):465-76.
14. Suárez-López del Amo F, Monje A, Padial-Molina M, Tang Z, Wang HL. Biologic agents for periodontal regeneration and implant site development. BioMed research international. 2015 5;2015.
15. Díaz-Sánchez RM, Yáñez-Vico RM, Fernández-Olavarría A, Mosquera-Pérez R, Iglesias Linares A, Torres-Lagares D. Current approaches of bone morphogenetic proteins in dentistry. Journal of Oral Implantology. 2015 ;41(3):337-42.
16. Abdulghani S, Mitchell GR. Biomaterials for in situ tissue regeneration: A review. Biomolecules. 2019 ;9(11):750.
17. Gupta RR, Gupta M, Garg A. Fibroblast Growth Factor (FGF): A Review. Dental Journal of Advance Studies. 2013 Aug;1(02):091-4.
18. Sasikumar KP, Elavarasu S, Gadagi JS. The application of bone morphogenetic proteins to periodontal and peri-implant tissue regeneration: A literature review. Journal of Pharmacy & Bioallied Sciences. 2012 ;4(Suppl 2):S427.
19. Hill DJ, Milner RD. Insulin as a growth factor. Pediatric research. 1985 Sep;19(9):879-86.