Authors : Dhanya Shree B.; Nafiya Taskeen M.; Santhanalakshmi V.; Renni Jovitta A.; Dr. D. P. Sivasakti Balan; R. J. Thaumamaswamy

Volume/Issue : Volume 11 - 2026, Issue 10 - October

Google Scholar : https://tinyurl.com/2vjuj6dk

DOI : https://doi.org/10.38124/ijisrt/26Oct457

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Alcohol metabolism is a complex biochemical process that occurs primarily in the liver and has significant effects on various organs, particularly the central nervous system. This study aims to develop a comprehensive understanding of the biochemical and physiological mechanisms involved in ethanol metabolism and its effects on human health. Following absorption into the bloodstream, ethanol is metabolized mainly in the liver through the action of alcohol dehydrogenase (ADH), which converts ethanol into acetaldehyde, and aldehyde dehydrogenase (ALDH), which further converts acetaldehyde into acetate. Acetaldehyde is a toxic intermediate that can contribute to cellular damage, while alcohol metabolism may also promote oxidative stress, inflammation, and disruption of normal cellular functions. Repeated and excessive alcohol consumption can lead to liver disorders, including fatty liver disease, alcoholic hepatitis, and cirrhosis. In addition, alcohol affects the central nervous system by altering neurotransmitter activity, particularly gamma-aminobutyric acid (GABA) and glutamate, thereby influencing memory, learning, judgment, coordination, and decision-making. Continued alcohol consumption may also contribute to the development of tolerance and dependence. This research focuses on ethanol absorption and metabolism, the functions of ADH and ALDH enzymes, the effects of acetaldehyde and oxidative stress, and the consequences of alcohol consumption on liver cells and brain function. Overall, the study highlights the importance of understanding the biochemical pathways of alcohol metabolism to explain alcohol-related tissue damage and its broader physiological effects on the human body.

Keywords : Ethanol Metabolism, Alcohol Dehydrogenase (ADH), Aldehyde Dehydrogenase (ALDH), Acetaldehyde, Oxidative Stress, Liver Damage, Neurotransmitters, Central Nervous System.

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