Authors : Devendrakumar Jain; Karunakar Shukla; Ragini Bundela

Volume/Issue : Volume 8 - 2023, Issue 6 - June

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/42meyfpp

DOI : https://doi.org/10.5281/zenodo.8115603

Abstract : Olmesartan medoxomil (OLM) is a frequently prescribed drug for the management of hypertension that works by blocking the angiotensin II receptor. OLM is classified as a class II medicine by the Biopharmaceutical Classification System (BCS) due to its weak solubility and bioavailability. The current work aims to create a self- micro-emulsifying drug delivery system (S-SMEDDS) to improve the solubility and availability of OLM. In this experiment, the liquid SMEDDS was formulated using the optimized mixture of carbitol, tween 20 and castor oil.Evaluation and characterization of the generated freeze-dried powder was carried out using various techniques. The powder has excellent flow qualities, according to the results.Furthermore, the freeze-dried powder in vitro dissolution study was compared to the marketed drug and plain drug.Results of in vitro dissolution investigation conclude that the freeze-dried powder form of S-SMEDDS of OLM boosts the solubility profile.

Keywords : Olmesartan medoxomil, Bioavailability, S- SMEDDS, Lipid-based formulation.