Hypertension, the silent killer has not only
increased mortality rates in adults but also is an
important risk factor for stroke, cardiac arrest, kidney
disease etc. There is a massive 30% prevalence of
hypertension in India. Heart Rate Variability (HRV) is a
physiological phenomenon of variation in the time
interval between heartbeats and is a gold-standard to
assess the perpetually changing oscillations of a
salubrious heart.
Aim
The purpose was to study the autonomic correlates
of cardiovasular health in hypertension in terms of short
term HRV and to analyse the association between HRV
indices and elevated blood pressure.
Methods
It was a cross-sectional observational study carried
out in Sports Physiology Laboratory in Department of
Physiology of a rural medical college in central India. 25
known cases of hypertension in the age group of 35-60
yrs and 75 age matched normotensives as controls were
selected. ECG was recorded using Power lab data
recording system, AD instruments and analysis was done
by HRV Module of Lab chart software. The subjects
performed an incremental ramp exercise test to the limit
of tolerance on a motorized treadmill.
Results
The mean age of control males was 39.80±6.68 and
mean age of control females was 37.05±2.75. There was
statistically significant difference observed in SDNN,
RMSSD, HF%, HFnu between control and cases males
but no significant relationship was observed among
other parameters in males. On comparing the sympathovagal ratio (LF/HF), female cases were having high ratio
than control females indicating a dominant sympathetic
response. From Pearson correlation analysis, a positive
non-significant relationship was observed between
systolic BP and Frequency domain indices in controls
while in cases a negative correlation was found which
was also statistically non-significant. A strong positive
correlation was found between Systolic BP and SDNN in
hypertensives. The time domain parameters were also
found to be negatively correlated with mean heart rate
in both controls and cases.
Conclusions
This study analysed the association between heart
rate variability indices and hypertension. The analysis
of HRV can distinguish parasympathetic from
sympathetic influences on the heart and provides
important insights into the role of the autonomic
nervous system in the pathogenesis of essential
hypertension. HRV is reduced in women along with men
accompanied by systemic hypertension. Among
normotensive men, lower HRV was associated with
greater risk for developing hypertension. These findings
clearly exhibit that autonomic dysregulation is present
in the early stage of hypertension.
Keywords :
Hypertension, HRV, Frequency Domain Indices, Time Domain Indices.