Authors :
Dr. Abhilash; Dr. KS Narang; Dr. Vikas Sharma
Volume/Issue :
Volume 8 - 2023, Issue 8 - August
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/4pp74nvm
DOI :
https://doi.org/10.5281/zenodo.8262528
Abstract :
Astroblastomas are regarded as uncommon
neuroepithelial tumors with an uncertain origin. These
tumors primarily affect young adults and children, mainly
in the cerebral hemisphere.2.8%. Because of their rarity in clinical practice
and their resemblance to other glial neoplasms in terms of
radiological and histopathologic appearance,
astroblastomas can be prone to misdiagnosis.
Case presentation: We report a 38-year-old female patient
who presented with vomiting and left-sided weakness.
Following a brain MRI, we observed a moderate-sized
area of T2 heterogeneous hyperintensity and T1
isointensity acute intraparenchymal bleed with mild
surrounding edema in the right high fronto-parietal
region. The dimensions of the bleed measured
approximately 4.1x3.9x3.4 cm. The MRI also revealed
some areas of mild diffusion restriction and faint
inhomogeneous areas of enhancement upon post-contrast
imaging. Furthermore, there was evidence of mild mass
effect on the right Posterior cingulate gyrus and a thin
streak of flair hyperintense subarachnoid bleed. To
address this condition, the patient underwent near-total
resection of the lesion and evacuation of the clot through
right fronto-parietal craniotomy. The diagnosis of low-
grade astroblastoma was confirmed through
histopathological examination combined with
immunohistochemical study.
Conclusion: Astroblastoma is an extremely rare primary
brain tumor. Its diagnosis often poses challenges due to the
astroblastic aspects found in astrocytic tumors,
ependymomas, and non-neuroepithelial tumors. The
histogenesis and classification of this tumor are
surrounded by considerable confusion. Conducting studies
to investigate tumor characteristics is difficult due to its
low incidence rate.
Astroblastomas are regarded as uncommon
neuroepithelial tumors with an uncertain origin. These
tumors primarily affect young adults and children, mainly
in the cerebral hemisphere.2.8%. Because of their rarity in clinical practice
and their resemblance to other glial neoplasms in terms of
radiological and histopathologic appearance,
astroblastomas can be prone to misdiagnosis.
Case presentation: We report a 38-year-old female patient
who presented with vomiting and left-sided weakness.
Following a brain MRI, we observed a moderate-sized
area of T2 heterogeneous hyperintensity and T1
isointensity acute intraparenchymal bleed with mild
surrounding edema in the right high fronto-parietal
region. The dimensions of the bleed measured
approximately 4.1x3.9x3.4 cm. The MRI also revealed
some areas of mild diffusion restriction and faint
inhomogeneous areas of enhancement upon post-contrast
imaging. Furthermore, there was evidence of mild mass
effect on the right Posterior cingulate gyrus and a thin
streak of flair hyperintense subarachnoid bleed. To
address this condition, the patient underwent near-total
resection of the lesion and evacuation of the clot through
right fronto-parietal craniotomy. The diagnosis of low-
grade astroblastoma was confirmed through
histopathological examination combined with
immunohistochemical study.
Conclusion: Astroblastoma is an extremely rare primary
brain tumor. Its diagnosis often poses challenges due to the
astroblastic aspects found in astrocytic tumors,
ependymomas, and non-neuroepithelial tumors. The
histogenesis and classification of this tumor are
surrounded by considerable confusion. Conducting studies
to investigate tumor characteristics is difficult due to its
low incidence rate.