Authors :
Bandan Thapa; Birendra Kumar Yada; Aabishkar Subedi; Bibek Joshi, M; Priya Yadav; Sharmila Lamichhane; Reshma Dahal
Volume/Issue :
Volume 9 - 2024, Issue 8 - August
Google Scholar :
https://tinyurl.com/425rnrpv
Scribd :
https://tinyurl.com/4dvhcphu
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24AUG587
Abstract :
Introduction:
Chronic liver disease (CLD) is a significant global
health concern, encompassing a range of liver
pathologies with varying degrees of severity. This cross-
sectional study aims to investigate the relationship
between platelet count and the severity of CLD. Platelet
count is a readily available and cost-effective clinical
parameter that may serve as a valuable prognostic
marker for CLD progression.
Materials and Method:
The study included 122 patients in Chitwan
Medical College Teaching Hospital (CMCTH) diagnosed
with CLD during one year starting from March 2022.
Data were collected using the proforma specially
designed for this study. Parameters like age and gender,
as well as brief clinical data, including liver function
tests, imaging findings, and platelet count, were
collected. Patients were then classified into different
stages of severity based on established criteria, i.e. child
Pugh Score system (CTP score). Statistical analyses were
performed using a statistical package for the social
science (SPSS); statistical program version 20.0, to
explore the association between platelet count and CLD
severity.
Results:
The majority of patients who had chronic liver
disease were found to be high in the age group of 40-60
years. Thrombocytopenia was found in 72.1% of chronic
liver disease patients. After classifying the severity of
chronic liver disease, it was found that 55.7% of patients
had a severe disease that was CTP-C, 36.1% were found
to be CTP-B and 8.2% were CTP-A. In patients with
normal platelet count, 44.1% had CTP-B, 41.2 had
CTPC and 14.7% had CTP-A score. In patients with
thrombocytopenia, 61.4% had CTP-C, 33.0% had CTP-
B and 5.7% had CTP-A score.
Conclusion:
This study provides a valuable snapshot of the
potential association between platelet count and the
severity of chronic liver disease. The prevalence of
thrombocytopenia across different disease stages
underscores its clinical relevance.
The platelet count is decreased in chronic liver
disease, however, it cannot be defined as the sole
predictor for the severity of CLD.
Keywords :
Chronic Liver Disease; Investigation; Platelet Count; Severity of Chronic Liver Disease; Thrombocytopenia.
References :
- Paik JM, Kabbara K, Eberly KE, Younossi Y, Henry L, Younossi ZM. Global burden of NAFLD and chronic liver disease among adolescents and young adults. Hepatology. 2022 May 21;75(5):1204–17.
- Garcia-Pagan JC, Francoz C, Montagnese S, Senzolo M, Mookerjee RP. Management of the major complications of cirrhosis: Beyond guidelines. J Hepatol. 2021 Jul;75:S135–46.
- Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019 Jan;70(1):151–71.
- BEHERA BP, Dash M. An observational study of clinical and hematological profile of cirrhosis of liver. Asian Journal of Pharmaceutical and Clinical Research. 2020 Feb 24;149–52.
- Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, et al. Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008 Jun;48(6):1000–7
Introduction:
Chronic liver disease (CLD) is a significant global
health concern, encompassing a range of liver
pathologies with varying degrees of severity. This cross-
sectional study aims to investigate the relationship
between platelet count and the severity of CLD. Platelet
count is a readily available and cost-effective clinical
parameter that may serve as a valuable prognostic
marker for CLD progression.
Materials and Method:
The study included 122 patients in Chitwan
Medical College Teaching Hospital (CMCTH) diagnosed
with CLD during one year starting from March 2022.
Data were collected using the proforma specially
designed for this study. Parameters like age and gender,
as well as brief clinical data, including liver function
tests, imaging findings, and platelet count, were
collected. Patients were then classified into different
stages of severity based on established criteria, i.e. child
Pugh Score system (CTP score). Statistical analyses were
performed using a statistical package for the social
science (SPSS); statistical program version 20.0, to
explore the association between platelet count and CLD
severity.
Results:
The majority of patients who had chronic liver
disease were found to be high in the age group of 40-60
years. Thrombocytopenia was found in 72.1% of chronic
liver disease patients. After classifying the severity of
chronic liver disease, it was found that 55.7% of patients
had a severe disease that was CTP-C, 36.1% were found
to be CTP-B and 8.2% were CTP-A. In patients with
normal platelet count, 44.1% had CTP-B, 41.2 had
CTPC and 14.7% had CTP-A score. In patients with
thrombocytopenia, 61.4% had CTP-C, 33.0% had CTP-
B and 5.7% had CTP-A score.
Conclusion:
This study provides a valuable snapshot of the
potential association between platelet count and the
severity of chronic liver disease. The prevalence of
thrombocytopenia across different disease stages
underscores its clinical relevance.
The platelet count is decreased in chronic liver
disease, however, it cannot be defined as the sole
predictor for the severity of CLD.
Keywords :
Chronic Liver Disease; Investigation; Platelet Count; Severity of Chronic Liver Disease; Thrombocytopenia.
