Acute coronary syndrome is one of many primary causes of mortality and morbidity in the world. Interventional therapy has been known to cause complications, which is in-stent restenosis (ISR). The CHA2DS2-VASc score consisted of 8 components that were thought to be associated with ISR. Several studies have suggested using the CHA2DS2-VASc score to predict the occurrence of ISR. Objective: The objective of this study was to determine whether the incidence of ISR in patients with acute coronary syndrome undergoing percutaneous coronary intervention at Haji Adam Malik General Hospital Medan was correlated with the CHA2DS2-VASc score. Methods: This was an observational analytic study, with a retrospective cohort design. The study was carried out at Haji Adam Malik General Hospital Medan since July 2020. The research sample was ACS patients at Haji Adam Malik General Hospital Medan. ISR was assessed by finding ≥50% narrowing of the stent or peri-stent segments luminal diameter at follow-up coronary angiography. To assess the relation between the CHA2DS2-VASc score and the incidence of ISR, bivariate analysis was performed. A p value < 0.05 was considered to be significant statistically. Results: From the total of 96 people, 46 (47.92%) of whom had ISR. The group that experienced ISR, in general, consisted of older mean age, more history of congestive heart failure, stroke, dyslipidemia, hypertension, and diabetes mellitus, as well as lower LVEF values, higher median FBG, lower mean HDL, and higher mean LDL. The variables that had a statistically significant association with ISR (p < 0.05) were hypertension, dyslipidemia, congestive heart failure, LVEF, HDL, LDL, and CHA2DS2-VASc score. Chi-square analysis of the CHA2DS2-VASc score and the incidence of ISR showed that the two variables had a significant correlation statistically (p < 0.0001; RR 14.58; CI = 6,026-44,997). Conclusion: The CHA2DS2-VASc score was statistically significant with the incidence of ISR in patients with ACS undergoing percutaneous coronary intervention at Haji Adam Malik General Hospital Medan (p < 0.001; RR 14.58; CI = 6,026-44,997). Patient characteristics that were significant statistically with the occurence of ISR were hypertension, dyslipidemia, congestive heart failure, LVEF, HDL, and LDL.

Keywords : CHA2DS2-VASc Score, In-Stent Restenosis, Acute Coronary Syndrome.