Authors :
Abdulkareem Qasem Moqbel; Lina Jamal Hameed; Emad Shamsan; Ram Prasad Chaulagain; Nand Lal; Radheshyam Gupta; Fikadu Balcha; Hongjuan Cui
Volume/Issue :
Volume 8 - 2023, Issue 9 - September
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/yr8xr3th
DOI :
https://doi.org/10.5281/zenodo.8413681
Abstract :
Background:
Obesity, characterized by excessive body fat
accumulation, can trigger inflammation and
independently disrupt vital organ functions like the liver.
This study aims to assess and compare the impact of
obesity on serum liver enzyme activity among obese and
non-obese Yemeni adult individuals.Methods:
A total of 250 healthy Yemeni individuals were
divided into two categories: 100 obese (BMI ≥25) and
150 non-obese (BMI <24.9). Data was collected via a
standard questionnaire. A semiautomatic instrument
was used to measure the activity of serum ALT, AST,
and GGT.Results:
The results revealed that the average age, weight,
height, and BMI of obese groups were substantially
higher than those of non-obese groups (P < 0.000). The
mean levels of ALT, AST, and GGT were higher in obese
groups when compared to non-obese groups (P < 0.000).
A significantly positive correlation of BMI with ALT,
AST, and GGT in obese groups (r = 0.329, P = 0.001, r =
0.280, P = 0.005, r = 0.213, P = 0.033; respectively). In
multiple linear regression analysis, obesity was
significantly independently associated with liver enzymes
of ALT (B=2.05, P = 0.002), AST (B=0.97, P = 0.050), and
GGT (B=1.64, P = 0.003) after adjustment for BMI.Conclusion:
Our study found significant increases in liver
enzymes (ALT, AST, GGT) among the obese group, with
stronger associations as BMI and obesity severity
increased. A comprehensive prospective study is
required to validate the interaction between obesity and
liver enzymes.
Keywords :
Liver Enzymes, ALT, AST, GGT, Obesity, BMI
Background:
Obesity, characterized by excessive body fat
accumulation, can trigger inflammation and
independently disrupt vital organ functions like the liver.
This study aims to assess and compare the impact of
obesity on serum liver enzyme activity among obese and
non-obese Yemeni adult individuals.Methods:
A total of 250 healthy Yemeni individuals were
divided into two categories: 100 obese (BMI ≥25) and
150 non-obese (BMI <24.9). Data was collected via a
standard questionnaire. A semiautomatic instrument
was used to measure the activity of serum ALT, AST,
and GGT.Results:
The results revealed that the average age, weight,
height, and BMI of obese groups were substantially
higher than those of non-obese groups (P < 0.000). The
mean levels of ALT, AST, and GGT were higher in obese
groups when compared to non-obese groups (P < 0.000).
A significantly positive correlation of BMI with ALT,
AST, and GGT in obese groups (r = 0.329, P = 0.001, r =
0.280, P = 0.005, r = 0.213, P = 0.033; respectively). In
multiple linear regression analysis, obesity was
significantly independently associated with liver enzymes
of ALT (B=2.05, P = 0.002), AST (B=0.97, P = 0.050), and
GGT (B=1.64, P = 0.003) after adjustment for BMI.Conclusion:
Our study found significant increases in liver
enzymes (ALT, AST, GGT) among the obese group, with
stronger associations as BMI and obesity severity
increased. A comprehensive prospective study is
required to validate the interaction between obesity and
liver enzymes.
Keywords :
Liver Enzymes, ALT, AST, GGT, Obesity, BMI
