The carried studies showed that extraction from grape seeds oil (registered as stepalol E) is a direct correlation agent between dimensions of ulcers and indicators of oxidative stress, and moreover, the capacity of grape seeds oil has a positive effect on the dynamics of the indicated processes. The obtained data enable us to consider that the extraction from grapes seeds oil is more reasonable to be included in the complex treatment of the patients with ulcer disease who have more manifested ulcer defects with a higher degree of H. pylori infection and higher activity of POL as the medicine has the evident cytoprotective, anti-helicobacterial and antioxidative actions.

Keywords : Stepalol E, Alcohol, Gastric Ulcer, Rat.