Authors : Mausumi Iqbal; Mezbah Ul Azeez; A. K. M. Shafiul Kadir; Ariful Haque; Mohammad Ullah Shemanto; Asheque Rahman

Volume/Issue : Volume 11 - 2026, Issue 5 - May

Google Scholar : https://tinyurl.com/bdhffssk

Scribd : https://tinyurl.com/5n6rvbzr

DOI : https://doi.org/10.38124/ijisrt/26May963

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Abstract : Squamous cell carcinoma antigen (SCCA) plays a pivotal role as a biomarker in various squamous cell carcinomas. This investigation delves into the potential of serum SCCA levels as a predictive tumor indicator in patients with oral squamous cell carcinoma (OSCC) undergoing definitive surgery. The research was carried out at a tertiary oral care center in Dhaka, Bangladesh, involving a cohort of 30 OSCC patients. The primary objectives were to evaluate the correlation between elevated serum SCCA levels and advanced-stage and poorly differentiated OSCC, as well as to assess SCCA's utility as a biomarker for early recurrence detection. The study, which transpired between July 2012 and June 2013, employed a cross-sectional analytical in vitro design. Preoperative and postoperative (within one week and three months) serum samples were collected from each patient to assess SCCA levels. The results demonstrated a compelling association between higher preoperative serum SCCA levels and advanced-stage, poorly differentiated OSCC. Among the 30 patients, three experienced disease recurrence, all of whom initially presented elevated SCCA levels, which subsequently normalized post-treatment, only to rise again within three months. In summary, the potential of serum SCCA levels as a valuable biomarker for identifying OSCC and assessing patient prognosis post curative surgery is evident. Utilizing SCCA levels alongside other diagnostic methods can augment early recurrence detection, ultimately contributing to improved patient outcomes.

Keywords : Squamous Cell Carcinoma Antigen, Oral Squamous Cell Carcinoma, Prognostic Tumor Marker, Recurrence Detection, Curative Surgery.

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