Assessment of Glycoconjugates Levels as Liability in Oral Precancerous and Oral Cancer Patients


Authors : Dr. Manjunath A. B.; Hemashree H. C.; Dr Ahamd Mujib B. R.; Dr. Deepashree P. Gujjar

Volume/Issue : Volume 9 - 2024, Issue 3 - March

Google Scholar : https://tinyurl.com/yck4cc4z

Scribd : https://tinyurl.com/4xywpmu7

DOI : https://doi.org/10.38124/ijisrt/IJISRT24MAR898

Abstract : Background: Because glycoproteins are crucial for maintaining the integrity of cells, dysglycoproteinemia has long been associated with cancer patients. The objective is to assess and correlate the serum glycoprotein levels in patients with oral cancer and possibly malignant illnesses. RESOURCES AND METHODS: There are 75 participants in this study, divided into three groups. Group 1: mouth cancer comprises 25 participants who have received a diagnosis of mouth cancer confirmed by histopathology. Group 2: Oral precancer comprises 25 participants who have been diagnosed with oral possibly malignant based on a histopathological confirmation. Group 3: A controlled group of twenty-five healthy volunteers, matched for age and sex.  Outcomes: The individuals in the OPM and OC group had significantly greater mean serum levels of protein bound hexose, total sialic acid, and fucose as compared to control.

Keywords : Dysglycoproteinmia, Oral Potentially Malignant, Serum PBH, Serum Total Sialic Acid, Serum Fucose.

Background: Because glycoproteins are crucial for maintaining the integrity of cells, dysglycoproteinemia has long been associated with cancer patients. The objective is to assess and correlate the serum glycoprotein levels in patients with oral cancer and possibly malignant illnesses. RESOURCES AND METHODS: There are 75 participants in this study, divided into three groups. Group 1: mouth cancer comprises 25 participants who have received a diagnosis of mouth cancer confirmed by histopathology. Group 2: Oral precancer comprises 25 participants who have been diagnosed with oral possibly malignant based on a histopathological confirmation. Group 3: A controlled group of twenty-five healthy volunteers, matched for age and sex.  Outcomes: The individuals in the OPM and OC group had significantly greater mean serum levels of protein bound hexose, total sialic acid, and fucose as compared to control.

Keywords : Dysglycoproteinmia, Oral Potentially Malignant, Serum PBH, Serum Total Sialic Acid, Serum Fucose.

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