Authors :
Lalasa Mukku; Jyothi Thomas
Volume/Issue :
Volume 9 - 2024, Issue 5 - May
Google Scholar :
https://tinyurl.com/2dv2uuyy
Scribd :
https://tinyurl.com/ytxwf685
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAY989
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Artificial Intelligence (AI) is a quickly evolving
field of technology used to develop intelligent machines
capable of performing tasks such as problem solving,
decision making , perception, language processing, and
learning. This paper explores the application of AI in the
field of gynecological oncology, specifically in the
diagnosis of cervical cancer. The paper proposes a hybrid
AI model that uses a Gaussian mixture model and a deep
learning model to segment and classifies colposcope
images. The model performed with satisfactory
segmentation metrics of sensitivity, specificity, dice index,
and Jaccard index of 0.976, 0.989, 0.954, and 0.856,
respectively. This model aims to accurately classify cancer
and non-cancer cases from a colposcope image. The
results showed that this method could effectively segment
the colposcopy images and extract the cervix region. This
can be a valuable tool for automated cancer diagnosis and
can help improve the diagnosis's accuracy.
Keywords :
Cervical Cancer, Gyno Oncology, Artificial Intelligence, Machine Learning, Gaussian Models.
References :
- Finlay J. An introduction to artificial intelligence. Crc Press; 2020.
- Bellman R. An introduction to artificial intelligence: can computers think? Thomson Course Technology; 1978.
- Shukla Shubhendu S, Vijay J. Applicability of artificial intelligence in different fields of life. Int J Sci Eng Res 2013;1:28–35.
- Davenport T, Kalakota R. The potential for artificial intelligence in healthcare. Futur Healthc J 2019;6:94.
- Yeasmin S. Benefits of artificial intelligence in medicine. 2019 2nd Int. Conf. Comput. Appl. Inf. Secur., IEEE; 2019, p. 1–6.
- Chen H-Y, Ge P, Liu J-Y, Qu J-L, Bao F, Xu C-M, et al. Artificial intelligence: Emerging player in the diagnosis and treatment of digestive disease. World J Gastroenterol 2022;28:2152.
- Schork NJ. Artificial intelligence and personalized medicine. Precis Med Cancer Ther 2019:265–83.
- Noguerol TM, Paulano-Godino F, Martín-Valdivia MT, Menias CO, Luna A. Strengths, weaknesses, opportunities, and threats analysis of artificial intelligence and machine learning applications in radiology. J Am Coll Radiol 2019;16:1239–47.
- Recht MP, Dewey M, Dreyer K, Langlotz C, Niessen W, Prainsack B, et al. Integrating artificial intelligence into the clinical practice of radiology: challenges and recommendations. Eur Radiol 2020;30:3576–84.
- Mysona DP, Kapp DS, Rohatgi A, Lee D, Mann AK, Tran P, et al. Applying artificial intelligence to gynecologic oncology: a review. Obstet Gynecol Surv 2021;76:292–301.
- Emin EI, Emin E, Papalois A, Willmott F, Clarke S, Sideris M. Artificial intelligence in obstetrics and gynaecology: is this the way forward? In Vivo (Brooklyn) 2019;33:1547–51.
- Guerriero S, Pascual M, Ajossa S, Neri M, Musa E, Graupera B, et al. Artificial intelligence (AI) in the detection of rectosigmoid deep endometriosis. Eur J Obstet Gynecol Reprod Biol 2021;261:29–33.
- Akazawa M, Hashimoto K. Artificial intelligence in ovarian cancer diagnosis. Anticancer Res 2020;40:4795–800.
- Timmerman D, Verrelst H, Bourne TH, De Moor B, Collins WP, Vergote I, et al. Artificial neural network models for the preoperative discrimination between malignant and benign adnexal masses. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 1999;13:17–25.
- Acharya UR, Molinari F, Sree SV, Swapna G, Saba L, Guerriero S, et al. Ovarian tissue characterization in ultrasound: a review. Technol Cancer Res Treat 2015;14:251–61.
- Acharya UR, Saba L, Molinari F, Guerriero S, Suri JS. Ovarian tumor characterization and classification: A class of GyneScanTM systems. 2012 Annu. Int. Conf. IEEE Eng. Med. Biol. Soc., IEEE; 2012, p. 4446–9.
- Toğaçar M. Detection of segmented uterine cancer images by Hotspot Detection method using deep learning models, Pigeon-Inspired Optimization, types-based dominant activation selection approaches. Comput Biol Med 2021;136:104659.
- Hu L, Bell D, Antani S, Xue Z, Yu K, Horning MP, et al. An Observational Study of Deep Learning and Automated Evaluation of Cervical Images for Cancer Screening. JNCI J Natl Cancer Inst 2019;111:923–32. https://doi.org/10.1093/jnci/djy225.
- M. S, K. H, A. H, Y. M, K. K, K. T, et al. application of deep learning to the classification of images from colposcopy. Oncol Lett 2018;15:3518–23.
- Perkins R, Jeronimo J, Hammer A, Novetsky A, Guido R, del Pino M, et al. Comparison of accuracy and reproducibility of colposcopic impression based on a single image versus a two-minute time series of colposcopic images. Gynecol Oncol 2022;167:89–95. https://doi.org/https://doi.org/10.1016/j.ygyno.2022.08.001.
- Singh Y, Srivastava D, Chandranand PS, Singh S. Algorithms for screening of Cervical Cancer: A chronological review. ArXiv 2018;abs/1811.0.
- Fragomeni SM, Moro F, Palluzzi F, Federico A, Bove S, Mascilini F, et al. 2022-RA-1299-ESGO How to predict preoperative risk of lymph node metastasis in vulvar cancer patients the Morphonode Predictive Model 2022.
- Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209–49. https://doi.org/10.3322/caac.21660.
- Rodríguez AC, Schiffman M, Herrero R, Hildesheim A, Bratti C, Sherman ME, et al. Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection. J Natl Cancer Inst 2010;102:315–24. https://doi.org/10.1093/jnci/djq001.
- Denny L, Quinn M, Sankaranarayanan R. Screening for cervical cancer in developing countries. Vaccine 2006;24:S71–7.
- Goldie SJ, Gaffikin L, Goldhaber-Fiebert JD, Gordillo-Tobar A, Levin C, Mahé C, et al. Cost-effectiveness of cervical-cancer screening in five developing countries. N Engl J Med 2005;353:2158–68.
- Ragothaman S, Narasimhan S, Basavaraj MG, Dewar R. Unsupervised Segmentation of Cervical Cell Images Using Gaussian Mixture Model. IEEE Comput Soc Conf Comput Vis Pattern Recognit Work 2016:1374–9. https://doi.org/10.1109/CVPRW.2016.173.
- Kim E, Huang X. A data driven approach to cervigram image analysis and classification. Lect Notes Comput Vis Biomech 2013;6:1–13. https://doi.org/10.1007/978-94-007-5389-1_1.
- Fang S, Yang J, Wang M, Liu C, Liu S. An Improved Image Classification Method for Cervical Precancerous Lesions Based on ShuffleNet. Comput Intell Neurosci 2022;2022:9675628. https://doi.org/10.1155/2022/9675628.
- Asiedu M, Ramanujam N, Sapiro G. Methods for automated detection of cervical pre-cancers with a low-cost, point-of-care, pocket colposcope 2021.
- Moldovan D. Cervical cancer diagnosis using a chicken swarm optimization based machine learning method. 2020 8th E-Health Bioeng Conf EHB 2020 2020:0–3. https://doi.org/10.1109/EHB50910.2020.09280215.
- Liu L, Wang Y, Liu X, Han S, Jia L, Meng L, et al. Computer-aided diagnostic system based on deep learning for classifying colposcopy images. Ann Transl Med 2021;9. https://doi.org/10.21037/atm-21-885.
- Peng G, Dong H, Liang T, Li L, Liu J. Diagnosis of cervical precancerous lesions based on multimodal feature changes. Comput Biol Med 2021;130:104209. https://doi.org/https://doi.org/10.1016/j.compbiomed.2021.104209.
- Ma S, Huang Y, Che X, Gu R. Faster RCNN-based detection of cervical spinal cord injury and disc degeneration. J Appl Clin Med Phys 2020;21:235–43. https://doi.org/10.1002/acm2.13001.
- Li Y, Chen J, Xue P, Tang C, Chang J, Chu C, et al. Computer-Aided Cervical Cancer Diagnosis Using Time-Lapsed Colposcopic Images. IEEE Trans Med Imaging 2020;39. https://doi.org/10.1109/TMI.2020.2994778.
- Meslouhi O El, Kardouchi M, Allali H, Gadi T, Benkaddour YA. Automatic detection and inpainting of specular reflections for colposcopic images. Open Comput Sci 2011;1:341–54. https://doi.org/10.2478/s13537-011-0020-2.
- Greenspan H, Gordon S, Zimmerman G, Lotenberg S, Jeronimo J, Antani S, et al. Automatic detection of anatomical landmarks in uterine cervix images. IEEE Trans Med Imaging 2009;28:454–68. https://doi.org/10.1109/TMI.2008.2007823.
- RamaPraba PS, Ranganathan H. Automatic lesion detection in colposcopy cervix images based on statistical features. Commun Comput Inf Sci 2012;270 CCIS:424–30. https://doi.org/10.1007/978-3-642-29216-3_46.
- Reynolds DA. Gaussian mixture models. Encycl Biometrics 2009;741.
- Do CB. The multivariate Gaussian distribution. Sect Notes, Lect Mach Learn CS 2008;229.
- Wang L, Chen Y, Pan X, Hong X, Xia D. Level set segmentation of brain magnetic resonance images based on local Gaussian distribution fitting energy. J Neurosci Methods 2010;188:316–25.
- Song D, Kim E, Huang X, Patruno J, Muñoz-Avila H, Heflin J, et al. Multimodal entity coreference for cervical dysplasia diagnosis. IEEE Trans Med Imaging 2014;34:229–45.
- Kageyama S, Mori N, Mugikura S, Tokunaga H, Takase K. Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. Eur Radiol 2021;31:55–64.
- Pulli K, Baksheev A, Kornyakov K, Eruhimov V. Real-time computer vision with OpenCV. Commun ACM 2012;55:61–9.
- Torralba A, Russell BC, Yuen J. Labelme: Online image annotation and applications. Proc IEEE 2010;98:1467–84.
- Suthaharan S, Suthaharan S. Support vector machine. Mach Learn Model Algorithms Big Data Classif Think with Examples Eff Learn 2016:207–35.
- Thomas J, Kulanthaivel G. Preterm Birth Prediction Using Cuckoo Search Based Fuzzy Min-Max Neural Network. Int Rev Comput Softw 2013;8:1854–62.
- Lipschuetz M, Guedalia J, Rottenstreich A, Persky MN, Cohen SM, Kabiri D, et al. Prediction of vaginal birth after cesarean deliveries using machine learning. Am J Obstet Gynecol 2020;222:613-e1.
- Akter L, Akhter N. Ovarian cancer prediction from ovarian cysts based on TVUS using machine learning algorithms. Proc. Int. Conf. Big Data, IoT, Mach. Learn. BIM 2021, Springer; 2022, p. 51–61.
- Stanzione A, Cuocolo R, Del Grosso R, Nardiello A, Romeo V, Travaglino A, et al. Deep myometrial infiltration of endometrial cancer on MRI: A radiomics-powered machine learning pilot study. Acad Radiol 2021;28:737–44.
Artificial Intelligence (AI) is a quickly evolving
field of technology used to develop intelligent machines
capable of performing tasks such as problem solving,
decision making , perception, language processing, and
learning. This paper explores the application of AI in the
field of gynecological oncology, specifically in the
diagnosis of cervical cancer. The paper proposes a hybrid
AI model that uses a Gaussian mixture model and a deep
learning model to segment and classifies colposcope
images. The model performed with satisfactory
segmentation metrics of sensitivity, specificity, dice index,
and Jaccard index of 0.976, 0.989, 0.954, and 0.856,
respectively. This model aims to accurately classify cancer
and non-cancer cases from a colposcope image. The
results showed that this method could effectively segment
the colposcopy images and extract the cervix region. This
can be a valuable tool for automated cancer diagnosis and
can help improve the diagnosis's accuracy.
Keywords :
Cervical Cancer, Gyno Oncology, Artificial Intelligence, Machine Learning, Gaussian Models.