Artificial Intelligence and Machine Learning in Early Detection and Prediction of Mild Cognitive Impairment (MCI): A Comprehensive Review


Authors : Ajeet Singh; Akash Tiwari; Dr. Manju Pandey; Dr. Avneesh Kumar; Shubham Goutam; Dr. Devendra Kumar Rawat; Vinay Vipin Tripathi

Volume/Issue : Volume 10 - 2025, Issue 12 - December


Google Scholar : https://tinyurl.com/45kycbz4

Scribd : https://tinyurl.com/yw448p54

DOI : https://doi.org/10.38124/ijisrt/25dec048

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Abstract : Mild Cognitive Impairment (MCI) is in an intermediate state between normal aging and dementia, the early detection of which is particularly important for early treatment and better prognosis. Recent developments in Artificial Intelligence (AI) and Machine Learning (ML) have indeed considerably improved the capabilities of detecting subtle cognitive, behavioral and neurobiological alterations linked to MCI. In this comprehensive review, we analyze the recent AI and ML methods employed in predicting MCI as well as detecting MCI and cover implementations of artificial intelligence assisted disease detection from supervised learning, unsupervised learning to deep learning models across various heterogeneous datasets like neuroimaging, cognitive assessment scores, speech patterns, genetic biomarkers data a-3 nd digital behavioral data. Mild Cognitive Impairment (MCI) is in an intermediate state between normal aging and dementia, the early detection of which is particularly important for early treatment and better prognosis. Recent developments in Artificial Intelligence (AI) and Machine Learning (ML) have indeed considerably improved the capabilities of detecting subtle cognitive, behavioral and neurobiological alterations linked to MCI. In this comprehensive review, we analyse the recent AI and ML methods employed in predicting MCI as well as detecting MCI and cover implementations of artificial intelligence assisted disease detection from supervised learning, unsupervised learning to deep learning models across various heterogeneous datasets like neuroimaging, cognitive assessment scores, speech patterns, genetic biomarkers data a- 3 nd digital behavioral data. This review also points out obstacles—such as data inconsistency, small dataset sizes, bias in algorithms, and difficulty in interpreting models—that impede clinical application. Nonetheless, existing trends suggest significant potential for AI- driven systems to assist healthcare providers, improve screening processes, and facilitate real-time monitoring via digital health instruments. In the end, AI and machine learning present hopeful opportunities for early identification, prognosis, and prevention of mild cognitive impairment, aiding in more effective long-term management of cognitive health.

Keywords : Artificial Intelligence, Machine Learning, Mild Cognitive Impairment, Early Detection, Prediction Models, Neuroimaging.

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Mild Cognitive Impairment (MCI) is in an intermediate state between normal aging and dementia, the early detection of which is particularly important for early treatment and better prognosis. Recent developments in Artificial Intelligence (AI) and Machine Learning (ML) have indeed considerably improved the capabilities of detecting subtle cognitive, behavioral and neurobiological alterations linked to MCI. In this comprehensive review, we analyze the recent AI and ML methods employed in predicting MCI as well as detecting MCI and cover implementations of artificial intelligence assisted disease detection from supervised learning, unsupervised learning to deep learning models across various heterogeneous datasets like neuroimaging, cognitive assessment scores, speech patterns, genetic biomarkers data a-3 nd digital behavioral data. Mild Cognitive Impairment (MCI) is in an intermediate state between normal aging and dementia, the early detection of which is particularly important for early treatment and better prognosis. Recent developments in Artificial Intelligence (AI) and Machine Learning (ML) have indeed considerably improved the capabilities of detecting subtle cognitive, behavioral and neurobiological alterations linked to MCI. In this comprehensive review, we analyse the recent AI and ML methods employed in predicting MCI as well as detecting MCI and cover implementations of artificial intelligence assisted disease detection from supervised learning, unsupervised learning to deep learning models across various heterogeneous datasets like neuroimaging, cognitive assessment scores, speech patterns, genetic biomarkers data a- 3 nd digital behavioral data. This review also points out obstacles—such as data inconsistency, small dataset sizes, bias in algorithms, and difficulty in interpreting models—that impede clinical application. Nonetheless, existing trends suggest significant potential for AI- driven systems to assist healthcare providers, improve screening processes, and facilitate real-time monitoring via digital health instruments. In the end, AI and machine learning present hopeful opportunities for early identification, prognosis, and prevention of mild cognitive impairment, aiding in more effective long-term management of cognitive health.

Keywords : Artificial Intelligence, Machine Learning, Mild Cognitive Impairment, Early Detection, Prediction Models, Neuroimaging.

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