Anti-trypanosomal Activities and Effect Garcinia kola Aqueous Seed Extract in Trypanosomiaisis Induced Wister Rat

Authors : Abiodun,Moses Oluwaseun; Ekesiobi, Anthony Obinna; Abiodun Iyabode Khadijat; Onyenweife, Leonard Chikwado

Volume/Issue : Volume 6 - 2021, Issue 11 - November

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This study investigated trypanosomal activity, haematological and lipid profile effects of Garcinia kola aqueous seed extract and Berenil drug in typanosomiasis induced Wistar rat. The extract was obtained through Maceration method with distilled water, In vitro activity of the extract and Berenil drug was determined using rapid matching techniques at 3 hours post incubation period with different doses of the extract and 3.5mg of Berenil drug. In vivo study was done using 62 Wister rats, divided into 10 groups. Group A (normal control): non infected and non treated, Group (B-H) were infected by intra peritoneal inoculation of 1mL of parasitized blood containing 1.0105 /ml of T. brucei gambianse parasites and treated with different doses of Garcinia kola seed extract, 200 – 1400mg, Group I: infected and treated with standard drug dose, Group J: infected and non treated (Pathological control). The treatment lasted for 21 days at 3 days interval. Hematological and lipid profile effects were determined by colorimetric method. Data were analyzed statistically using Anova at 0.01 significant differences. Various hematological and lipid profile effects were observed in all the extract treated and control groups. Garcinia kola seed extract exhibited trypanosostatic at dose of <400mg and trypanocidal activity at doses > 400mg in both in vitro and in vivo, compared with trypanocidal activity of standard Berenil drug dose. Garcinia kola seed extract produced moderate side effect on haematological and lipids profile parameters of wistar rat at doses <400mg in the extract treated groups when compared with Berenil drug which produced higher toxicity effect on heamatological and lipid profile parameters at standard dose. This study revealed that Garcinia kola aqueous seed extract may be used to design drug for the treatment of trypanosomiasis at lower concentration therefore, the use of Berenil drug in human and animal treatment should be discontinued

Keywords : Trypanosomiasis, Trypanosostatic, Wister rat, Berenil, Garciniakola.


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