Authors : Vankodoth Sireesha; Gadila Sushma; Mekala Sai Charitha; Boddu Shirisha; Dr. T. Rama Rao

Volume/Issue : Volume 10 - 2025, Issue 5 - May

Google Scholar : https://tinyurl.com/4a4jf43d

DOI : https://doi.org/10.38124/ijisrt/25may865

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Anti-Synthetase Syndrome (ASS) is an autoimmune disorder characterized by autoantibodies against aminoacyl- tRNA synthetases, including the rarer anti-PL-7 antibody. This variant is often associated with severe multi-system involvement, including necrotizing myopathy, interstitial lung disease (ILD), and non-erosive arthritis. The clinical manifestations can overlap with other systemic conditions, posing challenges in diagnosis and management. The case report describes about a 57-year-old woman with diabetes, hypertension, and morbid obesity was bedridden due to growing limb weakening and edema for a month. Her diagnosis included necrotizing inflammatory myositis, pneumonia, quadriparesis, hypokalemia, and anemia, along with Anti-Synthetase Syndrome (PL-7 positive). Imaging showed thoracic compressive myelopathy and myositis. Clinical improvement was achieved by the use of IVIG, corticosteroids, antibiotics, and supportive care.

Keywords : Amino Acyl-tRNA Synthetases, Interstitial Lung Disease, Myositis, Anti PL-7.

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