Anti-Microbial Activity and Synthesis of 3-(Benzylideneamino)- 2,7-Dimethylbenzo- [4,5] Thieno [2,3-D] Pyrimidine-4-Ones


Authors : Dhananjay Pandya; Mamta Chauhan

Volume/Issue : Volume 8 - 2023, Issue 6 - June

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/msjbxhjx

DOI : https://doi.org/10.5281/zenodo.8217244

Abstract : A series of few 3-(benzylideneamino) -2,7- dimethyl-benzo[4,5]thieno[2,3-d]pyrimidine-4-one were prepared in laboratory. They were purified by manual column chromatography as well as re-crystallized from various solvents. Their structures were characterized by spectroscopy techniques such as Proton-NMR and Carbon-NMR. Their masses were detected by using Mass-spectrometry. They were screened for their therapeutic and pharmacological activities as a biological function. Some of the novel target compounds were found to have strong biological activities with respect to Itraconozole and Furacin standard drugs.

Keywords : 3-(benzylideneamino)- 2,7-dimethylbenzo[4,5] thieno-[2,3-d]pyrimidine-4-one, Antifungal activity, Antimicrobial activity, Minimal Inhibition Concentration.

A series of few 3-(benzylideneamino) -2,7- dimethyl-benzo[4,5]thieno[2,3-d]pyrimidine-4-one were prepared in laboratory. They were purified by manual column chromatography as well as re-crystallized from various solvents. Their structures were characterized by spectroscopy techniques such as Proton-NMR and Carbon-NMR. Their masses were detected by using Mass-spectrometry. They were screened for their therapeutic and pharmacological activities as a biological function. Some of the novel target compounds were found to have strong biological activities with respect to Itraconozole and Furacin standard drugs.

Keywords : 3-(benzylideneamino)- 2,7-dimethylbenzo[4,5] thieno-[2,3-d]pyrimidine-4-one, Antifungal activity, Antimicrobial activity, Minimal Inhibition Concentration.

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