Authors :
Tejesvi Mishra
Volume/Issue :
Volume 8 - 2023, Issue 6 - June
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/sshcxxrb
DOI :
https://doi.org/10.5281/zenodo.8126028
Abstract :
The numbers of probable neurotoxins are
rising day by day and pose a perilous neuro-
inflammation to the body. Currently, the evaluation of
neurotoxicity is the most accomplished assessment in
non-clinical as well as clinical studies. Mislaying
memory, frailty in body, clouded vision, headache, and
psychological un-certainty subsequently developing
cognitive puzzlement are some of the major signs of
progressive inflammation in brain. Asserted evidence in
research states that the activated microglia, a major part
of brain causes damage to the neurons present in central
nervous system. The pattern of over-activated microglial
cells followed by oxidative stress found to be the main
pathway involved in neurotoxicity. Many studies
support the involvement of reactive oxygen species
(ROS) generation in hippocampus leading to toxic
mediator’s release and suggest excitotoxicity involving
overload of Calcium ions in frontal cortex as a secondary
damage. With the evolution of animal model, there has
been research-based analysis which affirms that a
developmental inflammatory symptom in brain can be
induced by several drugs, chemicals, pesticides and can
lead to neurodegenerative disorders. This study indulges
with a descriptive remark on various rodent models
related to neuronal inflammation.
Keywords :
Heavy metals; Pesticides; ROS; Hippocampus; Neurotoxicity; Neurodegenerative diseases.
The numbers of probable neurotoxins are
rising day by day and pose a perilous neuro-
inflammation to the body. Currently, the evaluation of
neurotoxicity is the most accomplished assessment in
non-clinical as well as clinical studies. Mislaying
memory, frailty in body, clouded vision, headache, and
psychological un-certainty subsequently developing
cognitive puzzlement are some of the major signs of
progressive inflammation in brain. Asserted evidence in
research states that the activated microglia, a major part
of brain causes damage to the neurons present in central
nervous system. The pattern of over-activated microglial
cells followed by oxidative stress found to be the main
pathway involved in neurotoxicity. Many studies
support the involvement of reactive oxygen species
(ROS) generation in hippocampus leading to toxic
mediator’s release and suggest excitotoxicity involving
overload of Calcium ions in frontal cortex as a secondary
damage. With the evolution of animal model, there has
been research-based analysis which affirms that a
developmental inflammatory symptom in brain can be
induced by several drugs, chemicals, pesticides and can
lead to neurodegenerative disorders. This study indulges
with a descriptive remark on various rodent models
related to neuronal inflammation.
Keywords :
Heavy metals; Pesticides; ROS; Hippocampus; Neurotoxicity; Neurodegenerative diseases.
