Analgesic & Antidiarrheal Activities Investigation on Methanol Extract of Wendlandia Paniculata : In Vivo Approach

Authors : Md.Rashaduzzaman Razu; Mosabbira Rahman Mousumi

Volume/Issue : Volume 6 - 2021, Issue 1 - January

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Wendlandia paniculata is under Rubiaceae family and well known as“Mimri”, “Lodiannol” which is found throughout Hill Tracks areas of Bangladesh. Chakma Tribe within the Hill Tracts of Bangladesh uses its leaves to treat chest pain. Crushed Wendlandia paniculata leaves are rubbed on the chest to reduce pain. Plant leaves of Wendlandia paniculata have been investigated for the evaluation of biological activities. This study has been subjected to scrutinize pharmacological ideas of methanol extract of Wendlandia paniculata like central and peripheral analgesic and antidiarrheal activities. Evaluation of analgesic activity was applied by following two protocols e.g., tail immersion protocol where Morphine was used as a positive control (centrally) and acetic acid-induced pain sensation protocol in mice (peripherally). The methanol fraction exhibits significant analgesic activity both centrally and peripherally at the following doses of 200 mg/kg and 400 mg/kg body weight of mice. The Antidiarrheal potentiality was evaluated by using the protocol of Ricinoleic acid (castor oil) induced diarrhea in Swiss albino mice and exhibited anti-diarrheal activity with a significant decrease of diarrheal feculences in a contrast to the standard drug loperamide hydrochloride. The bioassay of the methanol extract of the leaves of Wendlandia paniculata justified the analgesic and antidiarrheal properties of the methanol extract and finally exhorts the test sample as a provenance of analgesic and anti-diarrheal agents as a crude drug source.

Keywords : Wendlandia Paniculata, Central And Peripheral Analgesic, Antidiarrheal, Morphine, Methanol Extract


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