Wendlandia paniculata is under Rubiaceae
family and well known as“Mimri”, “Lodiannol” which is
found throughout Hill Tracks areas of Bangladesh.
Chakma Tribe within the Hill Tracts of Bangladesh uses
its leaves to treat chest pain. Crushed Wendlandia
paniculata leaves are rubbed on the chest to reduce pain.
Plant leaves of Wendlandia paniculata have been
investigated for the evaluation of biological activities.
This study has been subjected to scrutinize
pharmacological ideas of methanol extract of
Wendlandia paniculata like central and peripheral
analgesic and antidiarrheal activities. Evaluation of
analgesic activity was applied by following two protocols
e.g., tail immersion protocol where Morphine was used
as a positive control (centrally) and acetic acid-induced
pain sensation protocol in mice (peripherally). The
methanol fraction exhibits significant analgesic activity
both centrally and peripherally at the following doses of
200 mg/kg and 400 mg/kg body weight of mice. The Antidiarrheal potentiality was evaluated by using the
protocol of Ricinoleic acid (castor oil) induced diarrhea
in Swiss albino mice and exhibited anti-diarrheal activity
with a significant decrease of diarrheal feculences in a
contrast to the standard drug loperamide hydrochloride.
The bioassay of the methanol extract of the leaves of
Wendlandia paniculata justified the analgesic and antidiarrheal properties of the methanol extract and finally
exhorts the test sample as a provenance of analgesic and
anti-diarrheal agents as a crude drug source.
Keywords : Wendlandia Paniculata, Central And Peripheral Analgesic, Antidiarrheal, Morphine, Methanol Extract