Authors :
Harish Khadka; Kemi KC; Jeena Sapkota; Shubhaseena Shakya; Sonam Phinjo Sherpa; John Francis Tangonan; Mina Tamang
Volume/Issue :
Volume 8 - 2023, Issue 6 - June
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/2m6er7ec
DOI :
https://doi.org/10.5281/zenodo.8154825
Abstract :
Solanum melongena Linn. is a herbaceous plant, with large felty leaves densely covered with tiny star-shaped
(stellate) hairs, white to purple flowers, elongated or pear shaped fruit and are grown mainly for food and medicinal
purpose. The aim of the study is to determine the analgesic activity of solanum melongena leaf ethanolic extract in swiss
albino mice by acetic acid induced writhing method and hot plate method. For each method, albino mice were randomized
and divided into 5 groups which received NSS, low dose(3.04gm/kg), middle dose(7.58gm/kg) and high dose leaf
extract(19.05mg/kg) and control drug as paracetamol for writhing method while tramadol was used for hot plate method.
The young leaves of Solanum melongena was washed with water, air-dried and grinded to a coarse powder. The ethanolic
extract was prepared by percolating the dried powder with 95% ethanol and was sent for rotavap to the School of
Pharmacy of EAC. Analgesia was measured by acetic acid writhing method and hot plate method. The number of
writhings and reaction time were observed and was statistically analyzed using t-test independent followed by ANOVA. In
T-test independent all groups even in negative control showed statistical significance. To compare between the group,
Anova was done. Again to compare within the groups, post hoc was done. Post hoc showed no analgesic activity among low
dose and NSS.
Solanum melongena Linn. is a herbaceous plant, with large felty leaves densely covered with tiny star-shaped
(stellate) hairs, white to purple flowers, elongated or pear shaped fruit and are grown mainly for food and medicinal
purpose. The aim of the study is to determine the analgesic activity of solanum melongena leaf ethanolic extract in swiss
albino mice by acetic acid induced writhing method and hot plate method. For each method, albino mice were randomized
and divided into 5 groups which received NSS, low dose(3.04gm/kg), middle dose(7.58gm/kg) and high dose leaf
extract(19.05mg/kg) and control drug as paracetamol for writhing method while tramadol was used for hot plate method.
The young leaves of Solanum melongena was washed with water, air-dried and grinded to a coarse powder. The ethanolic
extract was prepared by percolating the dried powder with 95% ethanol and was sent for rotavap to the School of
Pharmacy of EAC. Analgesia was measured by acetic acid writhing method and hot plate method. The number of
writhings and reaction time were observed and was statistically analyzed using t-test independent followed by ANOVA. In
T-test independent all groups even in negative control showed statistical significance. To compare between the group,
Anova was done. Again to compare within the groups, post hoc was done. Post hoc showed no analgesic activity among low
dose and NSS.
