Authors : Dr. Kavya; Dr. Raghavendra; Dr. Roopashri Kashyap; Dr. Gowri Bhandarkar; Dr. Ujwala Shetty; Dr. Ashwini Baliga

Volume/Issue : Volume 10 - 2025, Issue 5 - May

Google Scholar : https://tinyurl.com/msehnkmz

DOI : https://doi.org/10.38124/ijisrt/25may1892

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Background Central Giant Cell Granuloma (CGCG) is a benign intraosseous lesion of the jaws, exhibiting a variable clinical course. The aggressive variant is characterized by rapid expansion, cortical perforation, and a higher recurrence rate. Maxillary involvement, particularly in pediatric patients, is rare and often poses diagnostic and therapeutic challenges.  Case Presentation This case report describes a 13-year-old female presenting with a rapidly enlarging, painless swelling in the anterior maxilla. Clinical, radiographic, and histopathological findings confirmed the diagnosis of aggressive CGCG. Cone-beam computed tomography revealed cortical breach with extension into the maxillary sinus and nasal cavity. Surgical excision under general anesthesia was performed, followed by splint placement. Postoperative recovery was uneventful, and the patient remains under regular follow-up with no signs of recurrence to date.  Conclusion Early diagnosis and surgical intervention are crucial in managing aggressive CGCG, especially in pediatric patients, to prevent functional and esthetic complications. Radiographic assessment and histopathological confirmation remain vital for appropriate treatment planning and minimizing recurrence risk.

Keywords : Central Giant Cell Granuloma, Aggressive Lesion, Pediatric Maxilla, Jaw Tumor, Surgical Excision, CBCT.

References :

1. Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surgery, Oral Medicine, Oral Pathology. 1953 Jan 1;6(1):159-75.
2. Mariz BA, Migliorati CA, Alves FD, Penteado FD, Carvalho Filho NP, Santos‐Silva AR, Rocha AC. Successful denosumab treatment for central giant cell granuloma in a 9‐year‐old child. Special Care in Dentistry. 2021 Jul;41(4):519-25.
3. Wang Y, Le A, El Demellawy D, Shago M, Odell M, Johnson-Obaseki S. An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. Journal of Otolaryngology-Head & Neck Surgery. 2019 Jan;48(1):32.
4. Huguet G, Piot B, Cassagnau E, Simon JF, Lesclous P. Rare agressive form of giant-cell granuloma: a three years follow-up case report and discussion about medical therapeutic solutions. Journal of Oral Medicine and Oral Surgery. 2018 Dec 1;24(4):187-91.
5. Singh G, Kumar S, Kumar A. Central Giant Cell Granuloma of Maxilla: A Case Report. The Traumaxilla. 2023 Dec;5(1-3):38-41.