Authors :
Isah Jibrin; Kurawa, M. A; Mohammed, J; Stephen I. Audu; Mohammed, J; Bathiya, S. S
Volume/Issue :
Volume 5 - 2020, Issue 8 - August
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3mJ6H9r
DOI :
10.38124/IJISRT20AUG766
Abstract :
Mechanochemical synthesis of Co(II) and
Cu(II) aspirin complexes was carried out by simple
grinding of metal (II) acetates with aspirin without any
solvent. Also conventional preparation of the above
complexes was carried out for comparison purposes
using the solution-based method. The products of
mechanochemical synthesis were characterized by
comparison of solubility, melting points, conductivity
values, magnetic moment and IR analyses with those of
ligands and conventional solution-based products. The
IR spectral and analytical data of the complexes were
similar for both products of the two synthetic routes
suggesting the formation of identical compounds. Job’s
method analyses suggested 1:2 metal to ligand ratio.
The elemental analyses results revealed identical
percentage composition of each element found in the
products as compared to those of calculated
percentages. The complexes have low values of molar
conductance (4.24-6.60Ω-1
cm2mol-1
) implying that they
are non-electrolytes in DMSO. The complexes were all
soluble in dimethylformamide and dimethylsulfoxide.
The complexes were mostly soluble in non-polar
solvents. All the products decomposed at a temperature
range of 177.0-181.9oC higher than that of their ligand
revealing their more stable nature. The magnetic
moment values obtained proved the paramagnetic
nature of the synthesized complexes. The products and
the ligand were screened against three bacteria isolates;
Escherichia coli, Kledsiella pneumonia, Staphylococcus
aureus and two fungi isolates; Aspergillus fumigatus,
Mucus specie for antimicrobial activity. The results
shows that the ligand was inactive against all the test
organisms; the complexes were active in all test
concentration, with only Co(asp)2 complex inactive
against Staphylococcus Aureus at a concentration of
15µg/disc.
Keywords :
Mechanochemical, Ligand, Complex, Job’s Method, Antimicrobial, Aspirin
Mechanochemical synthesis of Co(II) and
Cu(II) aspirin complexes was carried out by simple
grinding of metal (II) acetates with aspirin without any
solvent. Also conventional preparation of the above
complexes was carried out for comparison purposes
using the solution-based method. The products of
mechanochemical synthesis were characterized by
comparison of solubility, melting points, conductivity
values, magnetic moment and IR analyses with those of
ligands and conventional solution-based products. The
IR spectral and analytical data of the complexes were
similar for both products of the two synthetic routes
suggesting the formation of identical compounds. Job’s
method analyses suggested 1:2 metal to ligand ratio.
The elemental analyses results revealed identical
percentage composition of each element found in the
products as compared to those of calculated
percentages. The complexes have low values of molar
conductance (4.24-6.60Ω-1
cm2mol-1
) implying that they
are non-electrolytes in DMSO. The complexes were all
soluble in dimethylformamide and dimethylsulfoxide.
The complexes were mostly soluble in non-polar
solvents. All the products decomposed at a temperature
range of 177.0-181.9oC higher than that of their ligand
revealing their more stable nature. The magnetic
moment values obtained proved the paramagnetic
nature of the synthesized complexes. The products and
the ligand were screened against three bacteria isolates;
Escherichia coli, Kledsiella pneumonia, Staphylococcus
aureus and two fungi isolates; Aspergillus fumigatus,
Mucus specie for antimicrobial activity. The results
shows that the ligand was inactive against all the test
organisms; the complexes were active in all test
concentration, with only Co(asp)2 complex inactive
against Staphylococcus Aureus at a concentration of
15µg/disc.
Keywords :
Mechanochemical, Ligand, Complex, Job’s Method, Antimicrobial, Aspirin
