Neurogenerative diseases are a few of the major causes behind degradation to human health and well-being. Diseases like Alzheimer’s and Parkinson’s are the major life threatening diseases that result in short lifespan and eventually death. Scientists have been trying their level best to figure out the potential causes of these diseases individually and have deciphered several approaches to cure the same. The long disputed role of Lewy bodies in causing neurodegenerative diseases is poorly understood which stands as the main hurdle in developing such neuroprotective therapies, since there has been a lot of evidence suggesting accumulation of Lewy bodies as causing these diseases. However, experts have failed to develop a preventive and a permanent approach to address these disorders. Since there is a lot of overlap in the symptom spectrum of these disorders, this review paper addresses the role of Lewy bodies in generating the same- thereby, providing a framework for permanent and preventive cure