Authors :
Ismael Coulibaly; Hanane Rida; Tarik Chékrine; Zineb Bouchbika; Nadia. Benchakroun; Hassan Jouhadi; Nezha. Tawfiq; Souha Sahraoui
Volume/Issue :
Volume 7 - 2022, Issue 9 - September
Google Scholar :
https://bit.ly/43uxUln
Scribd :
https://bit.ly/40jMauA
DOI :
https://doi.org/10.5281/zenodo.8099696
Abstract :
Neuroendocrine tumors (NETs) arise from
neuroendocrine cells and are mostly observed in the
gastrointestinal tract, pancreas, and lungs. NETs in the
oral and maxillofacial region are extremely rare. We
report a case of a 67-year-old man with an NET in the
mandible. The patient did not show any symptoms
except for remarkable jugular swelling. The lesion
appeared as a radiolucent honeycomb abnormality with
bone destruction on panoramic radiography. The
histopathologic diagnosis following a biopsy was NET.
Contrast-enhanced computed tomography (CT), 18Ffluorodeoxyglucose positron emission computed
tomography (18F-FDG PET/CT), showed tumor mass of
the soft parts of the right mandible with bone lysis
without lymph node, visceral or bone hypermetabolism .
He had three chemotherapy cures with good clinical and
radiological response followed by concomitant radio
chemotherapy 60Gy.The evolution was marked by a
febrile grade IV aplasia leading to the death of the
patient. Neuroendocrine carcinomas of mandible are
unusual. Their prognosis is overall bleak. The
morphological characteristics, the clinical aspects and
the therapeutic management of these tumors are
comparable to the neuroendocrine tumors of the lung.
Keywords :
Neuroendocrine Small Cell Carcinoma, Mandible, Radiotherapy, Chemotherapy, Surgery.
Neuroendocrine tumors (NETs) arise from
neuroendocrine cells and are mostly observed in the
gastrointestinal tract, pancreas, and lungs. NETs in the
oral and maxillofacial region are extremely rare. We
report a case of a 67-year-old man with an NET in the
mandible. The patient did not show any symptoms
except for remarkable jugular swelling. The lesion
appeared as a radiolucent honeycomb abnormality with
bone destruction on panoramic radiography. The
histopathologic diagnosis following a biopsy was NET.
Contrast-enhanced computed tomography (CT), 18Ffluorodeoxyglucose positron emission computed
tomography (18F-FDG PET/CT), showed tumor mass of
the soft parts of the right mandible with bone lysis
without lymph node, visceral or bone hypermetabolism .
He had three chemotherapy cures with good clinical and
radiological response followed by concomitant radio
chemotherapy 60Gy.The evolution was marked by a
febrile grade IV aplasia leading to the death of the
patient. Neuroendocrine carcinomas of mandible are
unusual. Their prognosis is overall bleak. The
morphological characteristics, the clinical aspects and
the therapeutic management of these tumors are
comparable to the neuroendocrine tumors of the lung.
Keywords :
Neuroendocrine Small Cell Carcinoma, Mandible, Radiotherapy, Chemotherapy, Surgery.