Authors :
Dr. Trupti Naikare; Dr. Rajendra Prakash Sharma; Dr. Konga Shankar Rao; Dr. Deepmala Kumawat; Dr. Geeta Choudhary; Dr. Divya Patil
Volume/Issue :
Volume 7 - 2022, Issue 6 - June
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3Ofq2MN
DOI :
https://doi.org/10.5281/zenodo.6692214
Abstract :
Mica has been proven to have anticancer
effects, however, there is not much data available on its
efficacy and treating mechanism. In Ayurveda- an Indian
system of medicine, a medicine named ‘Abhrak bhasma’,
is incinerated mica-based nano-material being used for
centuries to treat various respiratory conditions and lungrelated diseases. Nanoparticles are proven to have
advantages in cancer treatment. The purpose of this study
was to examine ‘ Abhrak Bhasma’ induced cytotoxicity on
the A549 cell line.
Method - Cytotoxicity was measured by MTT assay on
A549 cell line
Result - Mica nanoparticles at up to 200µ/mL for 24 hours
showed concentration dependant cytotoxic activity. The
calculated IC50 value was 168.60µg/mL
Conclusion - This is the first report showing that Abhrak
bhasma or mica nanoparticles induce cytotoxicity in A459
cells.
Mica has been proven to have anticancer
effects, however, there is not much data available on its
efficacy and treating mechanism. In Ayurveda- an Indian
system of medicine, a medicine named ‘Abhrak bhasma’,
is incinerated mica-based nano-material being used for
centuries to treat various respiratory conditions and lungrelated diseases. Nanoparticles are proven to have
advantages in cancer treatment. The purpose of this study
was to examine ‘ Abhrak Bhasma’ induced cytotoxicity on
the A549 cell line.
Method - Cytotoxicity was measured by MTT assay on
A549 cell line
Result - Mica nanoparticles at up to 200µ/mL for 24 hours
showed concentration dependant cytotoxic activity. The
calculated IC50 value was 168.60µg/mL
Conclusion - This is the first report showing that Abhrak
bhasma or mica nanoparticles induce cytotoxicity in A459
cells.
