Parental mental illnesses are a major biological and environmental risk factor to which many children are exposed. Around 15–23% of children globally live with a parent who has a mental illness (Leidesdorff et al.,2017). This high-risk group of people may indeed be greatly affected psychologically and physically, which affects the fellow children as well as other individuals in society. This study aims to address the mental health of children of parents who do have mental illnesses and the interventions that can provided to them, using evidence from a systematic literature review. The PICO approach was utilised to facilitate the search via evidence-based practise. The PRISMA Technique was followed. Springer Link, DOAJ, PubMed, and Taylor & Francis databases were used to find studies. Examined the reference lists of the included research studies to find relevant publications to contextualise the study. The inclusion and exclusion criteria for the study have also been developed. Results of the study was Total data consists 12720 documents, out of which only 28 studies found to be considered to the present study. The data of the studies have indeed been gathered and divided into two sections: one on the mental health of children of parents with mental illness (COPMI), and the other on interventions to prevent the mental health of children of parents with mental illness (COPMI). The Recommendations and Suggestions have been given according to the results.

Keywords : Children of Parents with Mental Illness (Copmi), Parental Mental Illness, Mental Health of Copmi, Children’s Mental Health, Interventions for Copmi.