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A Study on the Efficacy of Ciprofloxacin Ear Drops Versus Ciprofloxacin with Dexamethasone Ear Drops in Patients with Otitis Externa at a Tertiary Care Hospital


Authors : Gopinath M.; Lokeshwari S.; Dr. K. Kannan; Dr. Ruta Shanmugam

Volume/Issue : Volume 11 - 2026, Issue 5 - May


Google Scholar : https://tinyurl.com/2eum8ftn

Scribd : https://tinyurl.com/mtj4jert

DOI : https://doi.org/10.38124/ijisrt/26May399

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Otitis externa is an inflammatory process in the external auditory canal, mostly due to bacterial infections, and involves signs like pain, discharge, tenderness, and swelling. This study intended to determine the comparative effectiveness of ciprofloxacin alone in relation to the combination of ciprofloxacin and dexamethasone in managing otitis externa. The study involved a prospective observation for six months at the ENT outpatient department of a tertiary care hospital in Tamil Nadu. Fifty patients with otitis externa were selected and randomly assigned to two groups, which included the use of ciprofloxacin alone or in combination with dexamethasone. Clinical results were measured through the Visual Analogue Scale (VAS) on Days 1, 7, and 14. Improvement in all symptoms was noted in both study groups over time. Nevertheless, a better effect was seen in combination therapy, especially in terms of reduction in pain, tenderness, swelling, and discharge after 14 days. Analysis of the data collected suggests that while initial effects were similar, the use of dexamethasone had a more beneficial effect after day seven. In Conclusion it can be said that ciprofloxacin in combination with dexamethasone works more effectively against otitis externa compared to ciprofloxacin alone because of its faster action. The addition of a steroid makes the therapy more effective due to a decrease in inflammation.

Keywords : Otitis Externa, Ciprofloxacin, Dexamethasone, Treatment Efficacy, Visual Analogue Scale.

References :

  1. Drehobl, M., Guerrero, J. L., Lacarte, P. R., Goldstein, G., Mata, F. S., & Luber, S. (2008). Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa. Current medical research and opinion , 24 (12), 3531-3542.
  2. Abelardo, E., Pope, L., Rajkumar, K., Greenwood, R., & Nunez, D. A. (2009). A double-blind randomised clinical trial of the treatment of otitis externa using topical steroid alone versus topical steroid–antibiotic therapy. European Archives of Oto-Rhino-Laryngology, 266(1), 41-45.
  3. Roland, P. S., Pien, F. D., Schultz, C. C., Henry, D. C., Conroy, P. J., Wall, G. M., ... & Stroman, D. W. (2004). Efficacy and safety of topical ciprofloxacin/dexamethasone versus neomycin/polymyxin B/hydrocortisone for otitis externa. Current medical research and opinion, 20(8), 1175-1183.
  4. Mösges, R., Domröse, C. M., & Löffler, J. (2007). Topical treatment of acute otitis externa: clinical comparison of an antibiotics ointment alone or in combination with hydrocortisone acetate. European archives of oto-rhino-laryngology, 264(9), 1087-1094
  5. Arms, E., & Dibb, W. L. (1993). Otitis externa: clinical comparison of local ciprofloxacin versus local oxytetracycline, polymyxin B, hydrocortisone combination treatment. Current medical research and opinion , 13 (3), 182-186.
  6. Rahman, A., Rizwan, S., Waycaster, C., & Wall, G. M. (2007). Pooled analysis of two clinical trials comparing the clinical outcomes of topical ciprofloxacin/dexamethasone otic suspension and polymyxin B/neomycin/hydrocortisone otic suspension for the treatment of acute otitis externa in adults and children. Clinical therapeutics, 29(9), 1950-1956.
  7. Haider, K. K., Al Robbani, A. M., Sattar, M. A., & Mamim, A. D. (2022). Pattern of otitis externa in ENT outpatient department of BSMMU, Dhaka, Bangladesh. Integrative Journal of Medical Sciences, 9, 1-10.
  8. Adegbiji, W. A., Aremu, S. K., Olatoke, F., Olajuyin, A. O., & Ogundipe, K. O. (2017). Epidemiology of otitis externa in developing country. International Journal of Recent Scientific Research, 8(6), 18023-18027.
  9. Wiegand, S., Berner, R., Schneider, A., Lundershausen, E., & Dietz, A. (2019). Otitis externa: investigation and evidence-based treatment. Deutsches Ärzteblatt International, 116(13), 224.
  10. Cassisi, N., Cohn, A., Davidson, T., & Witten, B. R. (1977). Diffuse otitis externa: clinical and microbiologic findings in the course of a multicenter study on a new otic solution. Annals of Otology, Rhinology & Laryngology, 86(3_suppl2), 1-16.

Otitis externa is an inflammatory process in the external auditory canal, mostly due to bacterial infections, and involves signs like pain, discharge, tenderness, and swelling. This study intended to determine the comparative effectiveness of ciprofloxacin alone in relation to the combination of ciprofloxacin and dexamethasone in managing otitis externa. The study involved a prospective observation for six months at the ENT outpatient department of a tertiary care hospital in Tamil Nadu. Fifty patients with otitis externa were selected and randomly assigned to two groups, which included the use of ciprofloxacin alone or in combination with dexamethasone. Clinical results were measured through the Visual Analogue Scale (VAS) on Days 1, 7, and 14. Improvement in all symptoms was noted in both study groups over time. Nevertheless, a better effect was seen in combination therapy, especially in terms of reduction in pain, tenderness, swelling, and discharge after 14 days. Analysis of the data collected suggests that while initial effects were similar, the use of dexamethasone had a more beneficial effect after day seven. In Conclusion it can be said that ciprofloxacin in combination with dexamethasone works more effectively against otitis externa compared to ciprofloxacin alone because of its faster action. The addition of a steroid makes the therapy more effective due to a decrease in inflammation.

Keywords : Otitis Externa, Ciprofloxacin, Dexamethasone, Treatment Efficacy, Visual Analogue Scale.

Paper Submission Last Date
31 - May - 2026

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