Authors : Amandeep Kaur; Brij Bhushan Sharma; Jyoti Pandir; Poonam Kumari; Dr. Rajneesh Kaur; Versha Sharma

Volume/Issue : Volume 10 - 2025, Issue 5 - May

Google Scholar : https://tinyurl.com/3kvxmpsa

DOI : https://doi.org/10.38124/ijisrt/25may1561

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Some of the most significant medications ever found are derived from fungi, and they have shown to be essential in the treatment of chronic illnesses. Not only have they prevented millions of deaths, but in certain instances, they have altered about the limits of medical advancement. With new businesses entering the market and hoping so use cutting-edge genomic technologies to speed up the discovery process, this might be about to change. This review looks at the path of discovery for both authorized fungal-derived medications and those undergoing clinical trials for long-term illnesses. We address the potential ecological roles of essential chemicals in nature and with how this connects to these application in human medicine. We demonstrate that how compounds meant to prohibit rival fungi, frequently interact with human receptors drug, sometimes with unanticipated benefits, due to conservation of drug receptors between fungi and people. In addition, we map the locations of medications, antimicrobial substances, and hallucinogenic mushrooms like fungal tree and focus on their distribution with that of all fungal metabolites. Lastly, we look at the self-resistance phenomena with fungi and how to predict the mechanism of metabolites and facilitate the drug discovery and lead optimization process.

Keywords : Secondary Metabolites Production, Fungal Metabolites Biosynthesis, Application of Fungi in Pharmaceuticals.

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