Authors : Aditya Bihani; Ramanuj Bajaj; Sanskruti Auti; Anshul

Volume/Issue : Volume 9 - 2024, Issue 11 - November

Google Scholar : https://tinyurl.com/24mpuavy

Scribd : https://tinyurl.com/bddb8fms

DOI : https://doi.org/10.5281/zenodo.14551392

Abstract : A cerebral aneurysm is a localized enlargement of a blood vessel in the brain caused by a weakened vessel wall. It typically appears as a bulge, balloon-like structure, or a small blister. Gaining insight into the mechanisms underlying the formation, growth, and rupture of cerebral aneurysms is crucial for devising treatments to mitigate the risks of mortality and severe complications. These aneurysms arise due to the thinning of arterial walls and are often difficult to detect until they rupture, leading to potentially life-threatening conditions such as hemorrhagic stroke, brain injury, visual impairments, and changes in behavior. Computational fluid dynamics (CFD) has proven valuable in studying cerebral aneurysms by modeling blood flow and analyzing hemodynamic parameters. These parameters play a critical role in assessing rupture risks and influencing biological processes within the affected vessels. This review examines the relationship between key hemodynamic factors and the formation, progression, and rupture of cerebral aneurysms. Additionally, it highlights how these factors are associated with the aneurysm's size, shape, and other morphological characteristics, shedding light on their significance in understanding aneurysm behavior.

Keywords : Cerebral Aneurysm, Hemodynamics, Wall Shear Stress, Rupture Risk, Ansys.

References :

1. View at: Publisher Site | Google Scholar H. H. Linn, G. J. E. Rinkel, A. Algra, and J. Van Gijn, “Incidence of subarachnoid hemorrhage: role of region, year, and rate of computed tomography: a meta-analysis,” Stroke, vol. 27, no. 4, pp. 625–629, 1996.
2. View at: Google Scholar R. Winn, J. A. Jane, J. Taylor, D. Kaiser, and A. G. W. Britz, “Prevalence of asymptomatic incidental aneurysms: review of 4568 arteriograms,” Journal of Neurosurgery, vol. 96, no. 1, pp. 43–49, 2002.
3. View at: Google Scholar S. Juvela, “Natural history of unruptured intracranial aneurysms: risks for aneurysm formation, growth, and rupture,” Acta Neurochirurgica, Supplement, no. 82, pp. 27–30, 2002.
4. View at: Google Scholar D. O. Wiebers, “Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment,” Lancet, vol. 362, no. 9378, pp. 103–110, 2003.
5. View at: Publisher Site | Google Scholar Cao and S. E. Rittgers, “Particle motion within in vitro models of stenosed internal carotid and left anterior descending coronary arteries,” Annals of Biomedical Engineering, vol. 26, no. 2, pp. 190–199, 1998.
6. View at: Google Scholar, S. Z. Zhao, X. Y. Xu, A. D. Hughes et al., “Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation,” Journal of Biomechanics, vol. 33, no. 8, pp. 975–984, 2000.
7. View at: Publisher Site | Google Scholar, P. Yoganathan, J. Ball, Y. R. Woo et al., “Steady flow velocity measurements in a pulmonary artery model with varying degrees of pulmonic stenosis,” Journal of Biomechanics, vol. 19, no. 2, pp. 129–146, 1986.
8. View at: Google Scholar, M. Nixon, M. Gunel, and B. E. Sumpio, “The critical role of hemodynamics in the development of cerebral vascular disease: a review,” Journal of Neurosurgery, vol. 112, no. 6, pp. 1240–1253, 2010.
9. View at: Publisher Site | Google Scholar, R. Cebral, M. A. Castro, S. Appanaboyina, C. M. Putman, D. Millan, and A. F. Frangi, “Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity,” IEEE Transactions on Medical Imaging, vol. 24, no. 4, pp. 457–467, 2005.
10. View at: Publisher Site | Google Scholar, Steinman, J. S. Milner, C. J. Norley, S. P. Lownie, and D. W. Holdsworth, “Image-based computational simulation of flow dynamics in a giant intracranial aneurysm,” American Journal of Neuroradiology, vol. 24, no. 4, pp. 559–566, 2003.