Authors :
Sagar Khokale; Dr. Laxmikant B Borse
Volume/Issue :
Volume 9 - 2024, Issue 5 - May
Google Scholar :
https://tinyurl.com/bdnpws9h
Scribd :
https://tinyurl.com/3drpww3t
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAY1667
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
In search for healthy, natural pain relief options
is still underway, and salicin from willow bark is a
historically significant molecule. The goal of this work is to
create a salicin-enriched topical gel formulation as a
cutting-edge method of treating pain and inflammation.
The objective of this study is to create and assess a salicin-
enriched gel made from willow bark, which may be used
topically to treat pain and inflammation in place of oral or
synthetic drugs. Willow bark was used to extract salicin,
which was then added to a topical gel base. The
permeability, salicin concentration, and physical stability
of the formulation were evaluated.Efficacy was evaluated
through in-vitro skin permeation studies and in-vivo anti-
inflammatory and analgesic models. The developed salicin-
enriched gel demonstrated good physical stability and
consistent release of salicin. In-vitro permeation studies
indicated effective skin absorption, while in-vivo tests
revealed significant reduction in inflammation and pain
indicators compared to controls. The gel was well-tolerated
with no adverse effects observed. The salicin-enriched gel
from willow bark represents a promising topical
alternative for pain and inflammation management. Its
efficacy and safety profile suggest potential for further
development and clinical use. Future studies focusing on
larger-scale clinical trials and formulation optimization
are warranted to fully establish its therapeutic value.
Keywords :
Salicin, Willow Bark, Topical Gel, Pain Management, Inflammation, Phytotherapy.
References :
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In search for healthy, natural pain relief options
is still underway, and salicin from willow bark is a
historically significant molecule. The goal of this work is to
create a salicin-enriched topical gel formulation as a
cutting-edge method of treating pain and inflammation.
The objective of this study is to create and assess a salicin-
enriched gel made from willow bark, which may be used
topically to treat pain and inflammation in place of oral or
synthetic drugs. Willow bark was used to extract salicin,
which was then added to a topical gel base. The
permeability, salicin concentration, and physical stability
of the formulation were evaluated.Efficacy was evaluated
through in-vitro skin permeation studies and in-vivo anti-
inflammatory and analgesic models. The developed salicin-
enriched gel demonstrated good physical stability and
consistent release of salicin. In-vitro permeation studies
indicated effective skin absorption, while in-vivo tests
revealed significant reduction in inflammation and pain
indicators compared to controls. The gel was well-tolerated
with no adverse effects observed. The salicin-enriched gel
from willow bark represents a promising topical
alternative for pain and inflammation management. Its
efficacy and safety profile suggest potential for further
development and clinical use. Future studies focusing on
larger-scale clinical trials and formulation optimization
are warranted to fully establish its therapeutic value.
Keywords :
Salicin, Willow Bark, Topical Gel, Pain Management, Inflammation, Phytotherapy.