⚠ Official Notice: www.ijisrt.com is the official website of the International Journal of Innovative Science and Research Technology (IJISRT) Journal for research paper submission and publication. Please beware of fake or duplicate websites using the IJISRT name.



A Multi-Modal Ayurvedic Intervention Combining Panchakarma, Herbal Medication, and CalorieRestricted Diet forType 2 Diabetes Mellitus


Authors : Dr. Rohit Sane; Dr. Gurudatta Amin; Dr. Pravin Ghadigaonkar; Dr. Priyadarshini Bhalekar; Dr. Trupti Pathare; Dr. Priyanka Pathare

Volume/Issue : Volume 11 - 2026, Issue 5 - May

Google Scholar : https://tinyurl.com/yc8x78rm

Scribd : https://tinyurl.com/5er39n3x

DOI : https://doi.org/10.38124/ijisrt/26May1648

PlumX Metrics

Semantic Scholar

ResearchGate

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Background: Type 2 Diabetes Mellitus (T2DM) is a growing metabolic disorder with rising prevalence globally. Conventional pharmacological management, while effective, is often associated with long-term side effects and medication dependence. Ayurveda offers a holistic approach to Prameha (diabetes) through multi-modal interventions addressing metabolic dysfunction at its root. This study evaluates the clinical outcomes of an integrated Ayurvedic protocol combining individualized Panchakarma therapies, oral herbal medications, and a structured low-calorie diet in patients with T2DM.  Methods: This retrospective observational study analyzed data from 29 patients (21 males, 8 females; mean age 45.4 ± 11.3 years) diagnosed with T2DM, treated at the Kharadi branch of a specialised Ayurvedic diabetes management clinic. Patients received one of two Panchakarma-based care plans — CDC-SP therapy (BMI ≥ 23) or CDC-KP therapy (BMI < 23) — comprising Snehan, Swedan, and Basti with a herbal preparation of Gudmar, Daru Haridra, and Yashti Madhu. All patients were concurrently prescribed oral herbal medications and an 800 kcal low-calorie, low-carbohydrate, highprotein, high-fat Prameha Diet Box. Primary outcomes included HbA1c and random blood sugar (RBS); secondary outcomes included body weight, BMI, abdominal girth, and blood pressure. Paired t-tests were used for pre/post comparisons.

Keywords : Type 2 Diabetes Mellitus · Panchakarma · Ayurveda · Prameha · Basti · HbA1c · Gudmar · Calorie-Restricted Diet · Integrative Medicine · Glycaemic Control · Madhavbaug · Koregaon Park.

References :

  1. International Diabetes Federation. IDF Diabetes Atlas, 11th edn. Brussels, Belgium: International Diabetes Federation, 2024. Available from: https://www.diabetesatlas.org
  2. GBD 2021 Diabetes Collaborators. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023;402(10397):203–234. doi:10.1016/S0140-6736(23)01301-6
  3. Anjana RM, Pradeepa R, Unnikrishnan R, et al. Geographical variation in the prevalence and risk factors of diabetes and prediabetes in India: results from the ICMR-INDIAB national study. Diabetologia. 2023;66(12):2252–2263.
  4. Charaka Samhita. Sutrasthana, Nidanasthana, Chikitsasthana. Varanasi: Chaukhamba Surbharati Prakashan; 2011.
  5. Sushruta Samhita. Chikitsasthana. Varanasi: Chaukhamba Sanskrit Pratishthan; 2010.
  6. Revandkar V, Lathi A, Jain A, et al. Role of Aahar and Panchakarma on restoration of euglycemia in patients of type 2 diabetes mellitus — a retrospective observational study. Int J Res Med Sci. 2023;11(11):4077–4081. doi:10.18203/2320-6012.ijrms20233297
  7. Kshirsagar J, Wankhade V, Nandedkar S, et al. Impact of Ayurvedic Panchakarma along with lifestyle modification in restoring glucose tolerance in type 2 diabetes mellitus. Int J Basic Clin Pharmacol. 2024;13(5):669–672.
  8. Hegde SV, Adhikari P, Bhuta S, Nagalakshmi MK, D'Souza V. Effect of a holistic program of yoga and Ayurvedic Panchakarma in type 2 diabetes mellitus: a pilot study. J Complement Integr Med. 2013;8. doi:10.2202/1553-3840.1365
  9. Chattopadhyay K, Chandrasekaran AM, Praveen PA, et al. Effectiveness and safety of Ayurvedic medicines in type 2 diabetes mellitus management: a systematic review and meta-analysis. Front Med. 2022;9:821810. doi:10.3389/fmed.2022.821810
  10. Laha S, Paul S. Anti-diabetic potential of Gymnema sylvestre: a review. Pharmacognosy J. 2019;11(6s):1111–1117.
  11. Porchezhian E, Dobriyal RM. An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. Pharmazie. 2003;58(1):5–12.
  12. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712–717. doi:10.1016/j.metabol.2008.01.013
  13. Fliegerová K, Mahayri TM, Sechovcová H, et al. Diabetes and gut microbiome. Front Microbiol. 2025;15:1487024. doi:10.3389/fmicb.2024.1487024
  14. Goldenberg JZ, Day A, Brinkworth GD, et al. Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis. BMJ. 2021;372:m4743. doi:10.1136/bmj.m4743
  15. Churuangsuk C, Hall J, Reynolds A, et al. Diets for weight management in adults with type 2 diabetes: an umbrella review. Diabetologia. 2022;65(1):14–36. doi:10.1007/s00125-021-05577-2
  16. Lean MEJ, Leslie WS, Barnes AC, et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes Endocrinol. 2019;7(5):344–355.
  17. Taheri S, Zaghloul H, Chagoury O, et al. Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I). Lancet Diabetes Endocrinol. 2020;8(6):477–489.
  18. McInnes N, Smith A, Otto R, et al. Remission of type 2 diabetes with very low-calorie diets — a narrative review. Nutrients. 2021;13(6):1890. doi:10.3390/nu13061890
  19. Li Y, Liu B, Zhao H, et al. Effects of low-carbohydrate diet on glucose and lipid metabolism in overweight or obese patients with type 2 diabetes: a meta-analysis of randomized controlled trials. Front Nutr. 2024;11:1516086.
  20. Gonzalez A, Krieg R, Massey HD, et al. Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression. Nephrology Dialysis Transplantation. 2019;34(5):783–794.
  21. Mohan V, Unnikrishnan R, Shanthi Rani CS. Are calorie-restricted diets safe in Indians? Indian J Med Res. 2021;153(3):321–323.
  22. Takeuchi T, Kubota T, Nakanishi Y, et al. Gut microbial carbohydrate metabolism contributes to insulin resistance. Nature. 2023;621(7978):389–395. doi:10.1038/s41586-023-06466-x

Background: Type 2 Diabetes Mellitus (T2DM) is a growing metabolic disorder with rising prevalence globally. Conventional pharmacological management, while effective, is often associated with long-term side effects and medication dependence. Ayurveda offers a holistic approach to Prameha (diabetes) through multi-modal interventions addressing metabolic dysfunction at its root. This study evaluates the clinical outcomes of an integrated Ayurvedic protocol combining individualized Panchakarma therapies, oral herbal medications, and a structured low-calorie diet in patients with T2DM.  Methods: This retrospective observational study analyzed data from 29 patients (21 males, 8 females; mean age 45.4 ± 11.3 years) diagnosed with T2DM, treated at the Kharadi branch of a specialised Ayurvedic diabetes management clinic. Patients received one of two Panchakarma-based care plans — CDC-SP therapy (BMI ≥ 23) or CDC-KP therapy (BMI < 23) — comprising Snehan, Swedan, and Basti with a herbal preparation of Gudmar, Daru Haridra, and Yashti Madhu. All patients were concurrently prescribed oral herbal medications and an 800 kcal low-calorie, low-carbohydrate, highprotein, high-fat Prameha Diet Box. Primary outcomes included HbA1c and random blood sugar (RBS); secondary outcomes included body weight, BMI, abdominal girth, and blood pressure. Paired t-tests were used for pre/post comparisons.

Keywords : Type 2 Diabetes Mellitus · Panchakarma · Ayurveda · Prameha · Basti · HbA1c · Gudmar · Calorie-Restricted Diet · Integrative Medicine · Glycaemic Control · Madhavbaug · Koregaon Park.

Paper Submission Last Date
30 - June - 2026

SUBMIT YOUR PAPER CALL FOR PAPERS
Video Explanation for Published paper

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe