A Litrerature Review N-Nitrosodimethylamine Contaminated Ranitidine Long-Term Use May Produce Cancer Risk


Authors : Priyanshu

Volume/Issue : Volume 8 - 2023, Issue 1 - January

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3H1hl68

DOI : https://doi.org/10.5281/zenodo.7557949

Ranitidine belongs is a histamine-2 blocker agent. Ranitidine is available in Tablet, Capsule, Syrup and Injection solution dosage form in market. Ranitidine is a prescription drug used to treat definite stomach and throat disease such as esophageal information, gastroesophageal reflux disease or GERD, and ZollingerEllison syndrome. It works by reducing the amount of gastric acid secretion . It relieves various symptoms such as chronic cough , stomach pain, heartburn, and painful blockage. It also used in treatment of stomach ulcers and intestineal ulcers. In April 2020, the United state Food and Drug Administration (FDA) publish a guidelines to manufacturers to withdraw all prescription and over-thecounter (OTC) ranitidine drugs from the market after find out the presence of the contaminants known as NNitrosodimethylamine (NDMA) in ranitidine medications in excess concentration (famous brand Zantac).This Literature reviews the indications, mechanism of action, pharmacokinetics, administration, adverse effects, contraindications, Mechanism of NDMA release, Regulatory Agencies Laboratory testing of Ranitidine for NDMA presence, the clinical study of NDMA generation in Angiotensin II Receptor Blockers (ARBs) and ranitidine were compared to find the current contamination evidence, and Effect of storage conditions, Stomach and intestine condition impact on NDMA generation, lastly we compare through which route NMDA produce lesser and in which greater.

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29 - February - 2024

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