Authors :
Priyanshu
Volume/Issue :
Volume 8 - 2023, Issue 1 - January
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3H1hl68
DOI :
https://doi.org/10.5281/zenodo.7557949
Abstract :
Ranitidine belongs is a histamine-2 blocker
agent. Ranitidine is available in Tablet, Capsule, Syrup
and Injection solution dosage form in market. Ranitidine
is a prescription drug used to treat definite stomach and
throat disease such as esophageal information,
gastroesophageal reflux disease or GERD, and ZollingerEllison syndrome. It works by reducing the amount of
gastric acid secretion . It relieves various symptoms such
as chronic cough , stomach pain, heartburn, and painful
blockage. It also used in treatment of stomach ulcers and
intestineal ulcers. In April 2020, the United state Food
and Drug Administration (FDA) publish a guidelines to
manufacturers to withdraw all prescription and over-thecounter (OTC) ranitidine drugs from the market after
find out the presence of the contaminants known as NNitrosodimethylamine (NDMA) in ranitidine medications
in excess concentration (famous brand Zantac).This
Literature reviews the indications, mechanism of action,
pharmacokinetics, administration, adverse effects,
contraindications, Mechanism of NDMA release,
Regulatory Agencies Laboratory testing of Ranitidine for
NDMA presence, the clinical study of NDMA generation
in Angiotensin II Receptor Blockers (ARBs) and
ranitidine were compared to find the current
contamination evidence, and Effect of storage conditions,
Stomach and intestine condition impact on NDMA
generation, lastly we compare through which route
NMDA produce lesser and in which greater.
Ranitidine belongs is a histamine-2 blocker
agent. Ranitidine is available in Tablet, Capsule, Syrup
and Injection solution dosage form in market. Ranitidine
is a prescription drug used to treat definite stomach and
throat disease such as esophageal information,
gastroesophageal reflux disease or GERD, and ZollingerEllison syndrome. It works by reducing the amount of
gastric acid secretion . It relieves various symptoms such
as chronic cough , stomach pain, heartburn, and painful
blockage. It also used in treatment of stomach ulcers and
intestineal ulcers. In April 2020, the United state Food
and Drug Administration (FDA) publish a guidelines to
manufacturers to withdraw all prescription and over-thecounter (OTC) ranitidine drugs from the market after
find out the presence of the contaminants known as NNitrosodimethylamine (NDMA) in ranitidine medications
in excess concentration (famous brand Zantac).This
Literature reviews the indications, mechanism of action,
pharmacokinetics, administration, adverse effects,
contraindications, Mechanism of NDMA release,
Regulatory Agencies Laboratory testing of Ranitidine for
NDMA presence, the clinical study of NDMA generation
in Angiotensin II Receptor Blockers (ARBs) and
ranitidine were compared to find the current
contamination evidence, and Effect of storage conditions,
Stomach and intestine condition impact on NDMA
generation, lastly we compare through which route
NMDA produce lesser and in which greater.
