A Comprehensive Review on the Therapeutic Potential of Pectin


Authors : Sapna Shrikumar; Ambika P; Dheema P S; Jishana Shareef; Shobhana A; Sikha VV

Volume/Issue : Volume 9 - 2024, Issue 7 - July

Google Scholar : https://tinyurl.com/2cc6kccs

Scribd : https://tinyurl.com/4trwsbu3

DOI : https://doi.org/10.38124/ijisrt/IJISRT24JUL718

Abstract : In our present paper we have given a comprehensive review of the medical uses, chemistry and other application of pectin. Pectin has many relevant therapeutic uses which is needful for obtaining effective herbal formulation. Pectin is chemically polysaccharide obtained from many fruits and vegetables. It occurs naturally as partial methyl ester of a (1→4) linked (+) - polygalacturonate sequences interrupted with rhamnose residues the neutral sugars. Pectin molecules are namely: galactose, rabinose, xylose and fructose. Common types of pectin are high methoxypectin (HM) and low methoxy pectin (LM). HMP is the common type and labelled as “fast –or rapid-set” and ”slow-set” .fast-set HM is best for chunky jams and slow set HM work well for clear jellies.it is used pharmacologically for regulation of blood cholesterol level and act as antioxidant, antimicrobial and antidiabetic. We have compiled the pharmaceutical, chemical and pharmacological uses of pectin.

Keywords : Pectin, Pharmacology, Pharmaceutical Additive, Natural Stabilizer.

References :

  1. Abourriche A, Hannache H, Oumam M (2018) Elaboration of novel adsorbent from Moroccan oil shale using Plackett-Burman design. Chem Int 4:7–14.
  2. Br aconnot H, Recherches sur un nouvel acide universellement répandu dans tous les vegetaux. AnnChim Phys 2(28):173– 178 (1825). (p.178: … je propose le nom pectique, de clot ,or curd,..)
  3. Carpita, N.C. and Gibeaut, D.M. (1993) Structural models of primary cell walls in flowering Plants :consistency of molecular structure with physical properties of the walls during the, plant j 3,130                 
  4. The role of surface functional groups of pectin and pectin based materials onthe adsorption of heavy metal ions and dyes. Carbohydr Polym 2022, 276118789
  5. Noreen A, Akram J, Rasul I, Mansha A, Yaqoob N, Iqbal R, Tabasum S, Zuber M, Zia KM. Pectins functionalized biomaterials; a new viable approach for biomedical applications: a           
  6. Pérez CD, De ’Nobili MD, Rizzo SA, Gerschenson LN, Descalzo AM, Rojas AM. High. methoxyl pectin–methyl cellulose films with antioxidant activity at a functional food interface. J  Food Eng. 2013; 116:162–9
  7. Axelos, M.A.V. and Thibault, J.F. (1991). The chemistry of low-methoxyl pectin gelation. In The chemistry and technology of pectin, ed. R.H. Walter. (New York: Academic Press)
  8. Aydin, Z. and Akbuga, J. (1996). Preparation and evaluation of pectin beads. International Journal of Pharmaceutics, 137, pp. 133-136.
  9. Robert A. Baker. Reassessment of Some Fruit and Vegetable Pectin Levels. JOURNAL OF FOOD SCIENCE, 1997; 62(2): 225-229.
  10. Axelos, M.A.V. and Thibault, J.F. (1991). The chemistry of low-methoxyl pectin gelation. In The chemistry and technology of pectin, ed. R.H. Walter. (New York: Academic Press)
  11. Sood N, Mathur A (2013). Evaluation of pharmacological activities of pectin extracted from apple and citrus pomace. Int. J. Biol. Sci. 2(4):1203-1217.
  12. 226Chemistry of Pectin and Its Pharmaceutical Uses: A ReviewOaken full, D.G. (1991). The chemistry of high-methoxyl pectins. In The chemistry and technology of   pectin, ed. R.H. Walter. (New York: Academic Pres
  13. Thakur, B.R., et al. (1997). Chemistry and uses of pectin – A review. Critical Reviews in food science and Nutrition.                                   
  14. Kastner, H.; Einhorn-Stoll, U.; Senge, B. Structure formation in Sugar containing pectin gels—Influence of Ca2+ on the gelation of low-methoxylated pectin at acidic pH. Food Hydrocoll. 2012,
  15. Rolin C, Pectins and their manipulation, in: C. Seymour, P. Knox (Eds.), Commercial Pectins Preparation. Oxford Blackwell BocaRaton FL; 2002. p. 222-241.
  16. Sriamornsak P. Chemistry of pectin and its pharmaceutical use: A review. Silpakorn University International Journal 2003; 3(1-2): 206-228.
  17. Sundar Raj AA, Rubila S, Jayabalan R, Ranganathan TV. (2012). A review on pectin: Chemistry due to general properties of pectin and pharmaceutical uses. Scientific reports,1:  2, 1-   4
  18. Srivastav P and Malviya R. Sources of pectin, extraction and its application in pharmaceutical industry – An overview. Indian J.Nat. Prod.Resour2011; 2(1): 10.
  19. Kaur A and Kaur G. Mucoadhesive buccal patches based on interpolymer complexes of chitosan–pectin for delivery of carvedilol. Saudi Pharm J. 2012; 21-27. DOI: 10.1016/j.jsps.2011.04.005
  20. Mishra RK, Majeed, BA and Banthia AK Development and characterization of pectin/gelatin hydrogel membranes for wound dressing. Int.J. Plast. Technol.2011; 15(1): 82-95.
  21. Leroux J, Langendorff V, Schick G, Vaishnav V, Mazoyer J. Emulsion stabilizing properties of pectin. Food Hydrocoll. 2003; 17(4): 455 – 462.
  22. Cervantes-Paz B, Ornelas-Paz J, de J, Ruiz-Cruz S, Rios-Velasco C, Ibarra-Junquera V, Gardea-Bejar AA. Effects of pectin on lipid ́ digestion and possible implications for carotenoid bioavailability during pre-absorptive stages: Food Res. Int. 2017; 99:917-927.
  23. Cervantes-Paz B, Ornelas-Paz J, deJ, Ruiz-Cruz S, Rios-Velasco C, Ibarra-Junquera V,  Gardea-Bejar AA. Effects of pectin on lipid ́ digestion and possible implications for 927.
  24. Dickinson, E. Hydrocolloids at interfaces and the influence on the properties of dispersed systems. Food Hydrocolloids, 2003; 17(1):25-39.
  25. Schwartz SE, Levine RA, Singh A, Scheidecker JR, Track NS. Sustained pectin ingestion delays gastric emptying. Gastroenterology. 1982;83(4):812-817.
  26. Wicker L, Kim Y. Pectin and health.in Encyclopedia of Food and Health,2016; 289-293. https://doi.org/10.1016/B978-0-12-384947-2.00532-8
  27. Miettinen, T. AMaksymowicz J, Palko-Łabuz A, Sobieszczańska B, Chmielarz M, Ferens-Sieczkowska M, Skonieczna M, et al. The Use of Endo-Cellulase and Endo-Xylanase forthe Extraction of Apple Pectins as Factors Modifying Their Anticancer Properties and Affecting Their Synergy with the Active Form of Irinotecan. Pharmaceuticals (Basel). 2022;15(6):732. doi:10.3390/ph15060732 idemicindividuals. linica Chimica Acta, 60, pp.1429-1431.
  28. Gullón, B.; Gómez, B.; Martínez-Sabajanes, M.; Yáñez, R.; Parajó, J.; Alonso, J. Pectic oligosaccharides: Manufacture and functional properties. Trends Food Sci. Technol. 2013, 30, 153–161.
  29. Joseph, G.H. (1956). Pectin: Bibliography of pharmaceutical literature. (Ontario: Sunkist 30, 153–161
  30. Sabra R, Billa N, Roberts CJ. An augmented delivery of the anticancer agent, curcumin, to the colon. React Funct Polym. 2018; 123:54–60.
  31. Oguntibeju OO. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. Int J Physiol Pathophysiol Pharmacol.2019;11(3):45.

In our present paper we have given a comprehensive review of the medical uses, chemistry and other application of pectin. Pectin has many relevant therapeutic uses which is needful for obtaining effective herbal formulation. Pectin is chemically polysaccharide obtained from many fruits and vegetables. It occurs naturally as partial methyl ester of a (1→4) linked (+) - polygalacturonate sequences interrupted with rhamnose residues the neutral sugars. Pectin molecules are namely: galactose, rabinose, xylose and fructose. Common types of pectin are high methoxypectin (HM) and low methoxy pectin (LM). HMP is the common type and labelled as “fast –or rapid-set” and ”slow-set” .fast-set HM is best for chunky jams and slow set HM work well for clear jellies.it is used pharmacologically for regulation of blood cholesterol level and act as antioxidant, antimicrobial and antidiabetic. We have compiled the pharmaceutical, chemical and pharmacological uses of pectin.

Keywords : Pectin, Pharmacology, Pharmaceutical Additive, Natural Stabilizer.

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe