Wound closure is assisted by the usage of appropriate suturing techniques and suture material in intra oral and general surgical procedures and aimed at maintaining form, function and aesthetics of surgical site. Wound closure can be done by suture materials, staples and tissue adhesives. Purpose of this study is to clinically compare the efficacy between tissue adhesive and standard suturing for wound closure after the piezocision.  Aims & Objectives Aim of the study was to compare the efficacy between tissue adhesive and standard suturing for wound closure after piezocision. The Objectives were to assess the surgical outcome of cyanoacrylate glue and conventional suture, and to compare surgical outcome of the both and also to establish an alternative to the conventional suture with emphasis on cost to benefit ratio.  Materials and Methods In this prospective, non-blinded study we have included 8 healthy consenting individuals of age group 16-30 years who were indicated to undergo peizocision/Modified corticotomy. Patients were divided into 2 groups. Group A in whom the wound closure was done with cyanoacrylate glue and Group B received interrupted routine conventional silk suture after wound closure.  Results The results were statistically significant and showed superior results in surgical glue group when compared with silk suture group for postoperative parameters.  Conclusion Cyanoacrylate is a better alternative for wound closures in minor oral surgical procedures as tissue glue was found to be haemostatic in nature, helpful in reduction of post operative pain and patients need to visit again for suture removal was not required. Moreover, this procedure was found to be comfortable for the surgeon. Future studies are required to evaluate long term results of intraoral usage to further its application. Research is needed for development of better tissue adhesives for usage in intraoral wounds.

Keywords : Peizocision, Cyanoacrylate Glue, Silk Suture, Intraoral Wound Closure, Piezosurgery