Authors :
Dr. Jale Venkat; Dr. Anwar. H. Mujawar
Volume/Issue :
Volume 10 - 2025, Issue 2 - February
Google Scholar :
https://tinyurl.com/mr2b9enh
Scribd :
https://tinyurl.com/baucw2wa
DOI :
https://doi.org/10.5281/zenodo.14979741
Abstract :
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary disorder characterized by
progressive renal cyst formation and extrarenal manifestations. While neurological complications such as intracranial
aneurysms and hypertensive encephalopathy are recognized, acute leukoencephalopathy remains an extremely rare
presentation. This case report discusses a 38-year-old male presenting with acute neurological symptoms, including
hemiparesis, dysarthria, and encephalopathy, ultimately diagnosed as ADPKD with uremic leukoencephalopathy.
Neuroimaging revealed bilateral white matter abnormalities suggestive of acute leukoencephalopathy. The patient’s condition
improved significantly after initiation of hemodialysis, highlighting the reversibility of metabolic encephalopathy in ADPKD.
This report underscores the importance of recognizing atypical neurological symptoms in ADPKD patients, emphasizing the
need for early diagnosis and timely intervention to prevent long-term complications.
References :
- Torres VE, Harris PC, Pirson Y. Autosomal Dominant Polycystic Kidney Disease. Lancet. 2007;369(9569):1287-301.
- Chapman AB, Johnson AM, Gabow PA. Neurologic Complications of ADPKD. Am J Kidney Dis. 1997;29(3):452-8.
- Dell KM, Avner ED. Polycystic Kidney Disease. Pediatr Clin North Am. 2003;50(6):1277-95.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary disorder characterized by
progressive renal cyst formation and extrarenal manifestations. While neurological complications such as intracranial
aneurysms and hypertensive encephalopathy are recognized, acute leukoencephalopathy remains an extremely rare
presentation. This case report discusses a 38-year-old male presenting with acute neurological symptoms, including
hemiparesis, dysarthria, and encephalopathy, ultimately diagnosed as ADPKD with uremic leukoencephalopathy.
Neuroimaging revealed bilateral white matter abnormalities suggestive of acute leukoencephalopathy. The patient’s condition
improved significantly after initiation of hemodialysis, highlighting the reversibility of metabolic encephalopathy in ADPKD.
This report underscores the importance of recognizing atypical neurological symptoms in ADPKD patients, emphasizing the
need for early diagnosis and timely intervention to prevent long-term complications.
