Thyroid hormones (TH) are having
significant effects on the nervous system. They are
important for the development of Central Nervous
System and myelination of neurons. Thyroid diseases can
lead to neuromuscular dysfunction.
Materials and Methods:The study was conducted in the
department of Physiology and department of Medicine
in J N Medical College, Aligarh. 50 patients with
hypothyroidism were included in the study. The
diagnosis of hypothyroidism was confirmed by serum
TSH levels. They were then sent for nerve conduction
study of Ulnar, Median and Sural nerve.
Results: There were significant changes in the latency,
amplitude and conduction velocity in the sensory nerve
conduction study of Ulnar, Median and Sural nerve on
Conclusion: Hypothyroidism manifests as
polyneuropathy which is mixed type. There is the
involvement of nerves in both upper and lower limbs
which can be diagnosed even before the occurrence of
other clinical symptoms in hypothyroidism. There is a
need to include sensory nerve conduction in the initial
workup of hypothyroid patients.
Keywords : Sensory, Nerve conduction, Hypothyroidism, Polyneuropathy.