A 48 Year Old Female with Quadriparesis Secondary to Sjögren's Syndrome with Atypical Presentation: A Case Report


Authors : Dr. Ameya Joshi; Dr. Jayaprakash A; Dr. Rekha S Patil

Volume/Issue : Volume 10 - 2025, Issue 2 - February

Google Scholar : https://tinyurl.com/28pz3ycc

Scribd : https://tinyurl.com/mrymmkp2

DOI : https://doi.org/10.5281/zenodo.14944981

Abstract : Sjögren's Syndrome is a autoimmune disease which is characterized by lymphocytic infiltration of exocrine glands, resulting in symptoms related to impaired exocrine gland, particularly lacrimal and salivary gland function such as xerostomia, keratoconjunctivitis sicca and profound B-cell Hyperactivity. The syndrome has unique features since it presents with a wide clinical spectrum from organ specific to systemic disease. The aim of this paper is to present a case of Sjögren's Syndrome, with atypical presentation as Quadriparesis. A 48 year old Female presented with acute onset, progressive muscle weakness of two day duration. On detailed evaluation, she was found to have low Potassium levels, Positive ANA Profile, Positive Schirmer’s Test, Distal Renal Tubular Acidosis. In our case, the patient primarily presented with Quadriparesis due Hypokalemic Periodic Paralysis due to distal RTA. Patient incidentally also had other features of Sjogren’s Syndrome including Dry eyes (Positive Schirmer’s Test), Xerostomia, Positive Rheumatoid Factor.

References :

  1. Dowd JE, Lipsky PE. Sjögren's syndrome presenting as hypokalemic periodic paralysis. Arthritis Rheum. 1993 Dec;36(12):1735-8. doi: 10.1002/art.1780361213. PMID: 8250993.
  2. Soy M, Pamuk ON, Gerenli M, Celik Y. A primary Sjögren's syndrome patient with distal renal tubular acidosis, who presented with symptoms of hypokalemic periodic paralysis: Report of a case study and review of the literature. Rheumatol Int. 2005 Nov;26(1):86-9. doi: 10.1007/s00296-005-0587-9. Epub 2005 Feb 3. PMID: 15690142.
  3. Taylor I, Parsons M. Hypokalemic paralysis revealing Sjögren's syndrome. J Clin Neurosci. 2004 Apr;11(3):319-21. doi: 10.1016/j.jocn.2003.04.004. PMID: 14975430.
  4. Loscalzo J, Fauci A, Kasper D, Hauser S, Longo D, Jameson J. eds. Harrison's Principles of Internal Medicine, 21e. McGraw Hill; 2022

Sjögren's Syndrome is a autoimmune disease which is characterized by lymphocytic infiltration of exocrine glands, resulting in symptoms related to impaired exocrine gland, particularly lacrimal and salivary gland function such as xerostomia, keratoconjunctivitis sicca and profound B-cell Hyperactivity. The syndrome has unique features since it presents with a wide clinical spectrum from organ specific to systemic disease. The aim of this paper is to present a case of Sjögren's Syndrome, with atypical presentation as Quadriparesis. A 48 year old Female presented with acute onset, progressive muscle weakness of two day duration. On detailed evaluation, she was found to have low Potassium levels, Positive ANA Profile, Positive Schirmer’s Test, Distal Renal Tubular Acidosis. In our case, the patient primarily presented with Quadriparesis due Hypokalemic Periodic Paralysis due to distal RTA. Patient incidentally also had other features of Sjogren’s Syndrome including Dry eyes (Positive Schirmer’s Test), Xerostomia, Positive Rheumatoid Factor.

Video Explanation for Published paper

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe